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Padres vs Giants Prediction & Betting

The San Diego Padres (3-1) are 3-0 in their last three games heading into their matchup against the San Francisco Giants (2-1) on Monday night. The Padres will try to extend their winning streak to four straight games as the winning Padres vs Giants prediction in San Francisco.

Padres vs Giants Betting Preview

Padres vs Giants Odds & Analysis

Opening Odds

The Giants opened as -185 favorites at home before steady betting action on San Diego as the preferred Padres vs Giants prediction drove the line down to San Francisco -143. San Diego is going off as a +133 underdog and the total in this NL West tilt is set at 8.5 runs. The OVER is 11-4 in San Francisco’s last 15 home games against San Diego.

Get the best Padres vs Giants odds and lines available from our recommended sportsbooks for your favorite picks of the night.

  • Best Spread
    -150
    +140
    SD+1.5
    -1.5SF
  • Best Moneyline
    +146
    -150
    SD
    SF
  • Best Total
    +105
    -115
    Over8.5
    8.5Under
 

Starting Pitchers

Nick Martinez was last seen in the majors recording an underwhelming 5.66 ERA in 23 appearances with the Texas Rangers back in 2017. Martinez spent the last four years pitching in Japan and is coming off a sensational season in the Japanese league in which he owned a 1.62 ERA and a 1.03 WHIP in 149.2 innings. He’ll start his second MLB stint Monday.

Alex Wood had a solid 2021 campaign in his first season with the Giants, compiling a 10-4 record with a 3.83 ERA and a 1.18 WHIP across 26 starts. Wood owns an impressive 2.85 ERA and a 1.12 WHIP in 66.1 career innings against San Diego.

San Diego Hoping To Turn Things Around Against NL West Foes

The Padres rolled to a 10-5 victory over the Arizona Diamondbacks on Sunday to secure their third straight win after a season-opening loss. San Diego set the tone early with a five-run second inning that was highlighted by a Jurickson Profar grand slam.

San Diego was 2-14 over its previous 16 games against NL West opponents prior to its three straight wins over the Diamondbacks. Bettors taking San Diego as their Padres vs Giants prediction are hoping that the Padres can carry the momentum of those three wins into more success within the division in this series.

San Francisco Looking To Prove Doubters Wrong Again

The Giants locked up a series win against the Miami Marlins with a 3-2 victory on Sunday, improving to 2-1 on the season in the process. All three of San Francisco’s games against the Marlins were one-run affairs as the Giants won 6-5 on Friday and lost 2-1 on Saturday.

San Francisco shocked the baseball world with a 107-win season in 2021. Most baseball fans and bettors are expecting a major regression from the Giants this season, but they’re out to prove that last season was no fluke, even if getting back to 100 wins may be a tall order.

Padres vs Giants Pick & Insights

Padres: Keys To Victory

If Nick Martinez can show the same dominance on Monday that he showed in his last season in Japan, the Padres could provide great betting value as a Padres vs Giants prediction here. The offense is playing well, so the outcome of this one could simply boil down to how well Martinez pitches.

Giants: Keys To Victory

Alex Wood was one of the many players on last year’s elite Giants team who outperformed expectations. He has historically pitched very well against the Padres and gives San Francisco its best shot at being the winning Padres vs Giants pick by keeping that trend going on Monday.

Odds Shark’s Computer Padres vs Giants Prediction: Giants -143

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Shark Bites
  • San Diego is 5-14 over its last 19 games.
  • San Francisco is 12-5 in its last 17 games.
  • The UNDER is 5-2 in San Diego’s last 7 road games.

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