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MLB Odds with Pick - San Francisco Giants vs Houston Astros

The San Francisco Giants pay a visit to Houston on Wednesday, hoping to shut down the Astros bats in baseball betting action at Minute Maid Park.

Brett Oberholtzer will take the mound for the Houston Astros, and he'll carry a 0-0 record into the contest. Tim Hudson gets the ball for the San Francisco Giants; he's 1-3 so far this season.

Opening Odds & Computer Pick

Baseball betting odds makers, including BetOnline, opened the Houston Astros as -106 moneyline favorites in this matchup. Over under total bettors saw the number open at 8.5 at shops such as Bovada.

Handicapping models based on recent betting stats and prediction formulas pick a 4.4-3.2 win for the Astros. A 4.4-3.2 result in favor of the Astros is the prediction by the Odds Shark handicapping pick engine. View the computer score prediction and who will win the pick on the moneyline for all upcoming MLB matchups here.

San Francisco Giants vs Houston Astros Matchup

Team Betting Records & Power Rankings

The Houston Astros sport a record of 20-13 heading into this matchup, while the San Francisco Giants sit at 17-16 on the season Stay Informed: follow us on Twitter for odds specials, betting line moves and Houston vs San Francisco injuries news.

It's a MLB baseball betting matchup between the No. 6-rated Houston Astros and the league No. 15-ranked San Francisco Giants, according to the latest MLB power poll here at Odds Shark.

Statistical Matchup

Offensively, the game matches up Houston Astros No. 16 ranked offense (4.27 runs per game) against a San Francisco Giants defense and pitching staff that sits at No. 9 at 3.79 runs allowed per game. The Houston Astros have been averaging 7.52 hits per game, less than the San Francisco Giants have managed so far this season (8.88 hits on average).

Pitching and defensive stats are important baseball handicapping betting factors and Houston has the No. 10-ranked defense. In the other dugout, the Giants own the No. 9 mark in runs allowed.

Recent Outings Betting Recap

San Francisco hopes solid pitching and defense that led to their last victory - a 10-strikeout performance from Chris Heston - will prevail again after their 8-1 victory against Houston at Minute Maid Park.

Betting Trends
  • San Francisco is 8-3 SU in its last 11 games
  • The total has gone OVER in 4 of San Francisco's last 6 games
  • San Francisco is 3-6 SU in its last 9 games on the road
  • San Francisco is 5-0 SU in its last 5 games when playing Houston
  • Houston is 16-7 SU in its last 23 games
  • Houston is 2-6 SU in its last 8 games
  • Houston is 1-4 SU in its last 5 games at home
  • The total has gone OVER in 4 of Houston's last 6 games at home

Next Betting Matchups

San Francisco at Cincinnati, Thursday, May 14th
Houston home to Toronto, Thursday, May 14th