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MLB Betting Line Favors the San Francisco Giants over the San Diego Padres

The MLB baseball betting odds board sees a clash between San Diego and San Francisco on Wednesday, with the host Padres trying to win for themselves and reward betting fans who pick them on the moneyline.

Johnny Cueto gets the ball in front of a hostile crowd for the San Francisco Giants on Wednesday; he's 5-1 on the season. The San Diego Padres, meanwhile, will counter with Drew Pomeranz, who will be looking to improve on his 4-3 mark.

Opening Odds & Computer Pick

Sportsbooks such as Bovada had installed the San Diego Padres as 133 moneyline underdogs in this particular MLB betting odds matchup. The total, meanwhile, was set early at 6.5 before betting at 5Dimes started to move the line.

Odds Shark computer prediction handicapping models run on this game pick a 5.5-2.0 victory for the Giants. View the computer score prediction and who will win the pick on the moneyline for all upcoming MLB matchups here.

San Francisco Giants vs San Diego Padres Matchup

Team Betting Records & Power Rankings

17-23 San Diego battles the Giants, currently with a 23-18 mark. Stay Informed: follow us on Twitter for odds specials, betting line moves and San Diego vs San Francisco injuries news.

This game matches up the No. 21 (San Diego Padres) and the No. 15 (San Francisco Giants) teams, according to our current MLB Power Rankings.

Statistical Matchup

Offensively, the game matches up San Diego Padres No. 28 ranked offense (3.62 runs per game) against a San Francisco Giants defense and pitching staff that sits at No. 16 at 4.37 runs allowed per game. The San Diego Padres have been averaging 7.72 hits per game, less than the San Francisco Giants have managed so far this season (8.98 hits on average).

San Diego owns the No. 15 defense, allowing 3.62 men per game to cross the plate. That contrasts with San Francisco's No. 16-rated defense.

Recent Outings Betting Recap

The Giants hope for a dominant pitching performance similar to their last game when M Bumgarner struck out 11 batters in 5-1 victory on Tuesday at PETCO Park.

Betting Trends
  • San Francisco is 5-0 SU in its last 5 games
  • The total has gone UNDER in 5 of San Francisco's last 5 games
  • San Francisco is 5-0 SU in its last 5 games on the road
  • The total has gone UNDER in 5 of San Francisco's last 5 games on the road
  • The total has gone UNDER in 5 of San Diego's last 6 games
  • San Diego is 2-4 SU in its last 6 games at home
  • The total has gone UNDER in 4 of San Diego's last 6 games at home
  • San Diego is 2-10 SU in its last 12 games when playing San Francisco

Next Betting Matchups

San Francisco at San Diego, Thursday, May 19th