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The San Diego Padres take on the San Francisco Giants on Monday night.

The San Diego Padres (61-50) are 0-4 SU over their last four games heading into this three-game series against the San Francisco Giants (53-55). The Padres will try to turn things around by cashing in as a Giants vs Padres prediction at home in this Monday night's series opener.

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Giants vs Padres Odds & Analysis

Opening Odds

The Padres opened as -161 favorites in this NL West showdown before betting action on them as a popular Giants vs Padres prediction drove the line up to San Diego -185. There was also significant action on the OVER in this matchup as the total has settled in at eight runs after opening at seven runs. The OVER is 6-2 in San Diego's last eight home games against San Francisco.

Starting Pitchers

Alex Wood pitched six innings and got lit up for nine hits and six earned runs in last Tuesday night's 9-5 Giants loss to the Los Angeles Dodgers. Wood had compiled a 1.65 ERA in the five starts prior to that one and he carries a 7-9 record with a 4.42 ERA and a 1.25 WHIP into this start against the Padres.

Blake Snell continued his recent stretch of strong pitching in San Diego's 9-1 win over the Colorado Rockies last Wednesday, pitching six innings and allowing only one earned run with nine strikeouts. Snell has allowed one run or fewer in five of his last six starts, bringing his season ERA down to 4.16 and his WHIP down to 1.33 in the process with 87 strikeouts in 67 innings pitched.

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San Francisco Snapped Road Slump Over The Weekend

The Giants entered their two-game road series against the Oakland Athletics with an 0-7 SU record in their last seven road games. San Francisco finally put an end to that road skid over the weekend with a 7-3 win on Saturday and a 6-4 win on Sunday.

This three-game road series against the Padres will offer a much sterner road test than the 41-68 SU Athletics did. San Francisco has won each of its last two games against San Diego since going 0-5 SU in its previous five games against them.

San Diego Failed Its Road Test In Los Angeles

There is no shame in losing to a team as good as the Los Angeles Dodgers. But after acquiring Juan Soto and Josh Bell before the MLB Trade Deadline, the Padres were hoping to prove they were a legitimate World Series contender over the weekend; and instead they lost all three games in Los Angeles by four runs or more and by a combined score of 20-4.

Now the Padres return home, where they are 5-1 SU over their last six games. Bettors taking San Diego as their Giants vs Padres prediction are hoping that home field advantage and a softer opponent leads to a Padres victory on Monday night.

Giants vs Padres Pick & Insights

Giants: Keys to Victory

The Giants are 12-14 SU over their last 26 games, but that slump is heavily skewed by an 0-8 SU record against the red-hot Dodgers. San Francisco's offense and pitching have performed   well enough against teams other than the Dodgers of late that there might actually be some value on them as a Giants vs Padres prediction underdog in this one.

Padres: Keys to Victory

Blake Snell's current stretch of dominance includes a 6-3 win over the Giants in which Snell pitched six innings and allowed only three hits and one run with 11 strikeouts. A similar outing on Monday night would likely put San Diego in position to score a win as a Giants vs Padres pick at home.

MLB Computer Pick: Giants +165 ML

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Shark Bites
  • San Francisco is 5-12 SU over its last 17 games.
  • San Diego is 31-23 SU at home this season.
  • The OVER is 4-1 in San Diego's last 5 games.