The San Diego Padres (82-66) are 4-0 over their last four games after defeating the St. Louis Cardinals (87-62) on Tuesday night. The Padres will look to extend their winning streak to five straight games with a win as a Cardinals vs Padres prediction favorite Wednesday night in San Diego. 

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Cardinals vs Padres Opening Odds

The Cardinals vs Padres odds on Wednesday opened with both clubs going off at -116, but betting action on the Padres has shifted the line to make San Diego a -132 favorite at home. St. Louis is now going off as a +122 road underdog and the total has settled in at 7.5 runs after opening at 7 runs. The UNDER is 4-2 in the last six games between the Padres and Cardinals.

Get the best Cardinals vs Padres odds and lines available from our recommended sportsbooks for your favorite picks of the night.

  • Best Spread
    -180
    +165
    STL+1.5
    -1.5SD
  • Best Moneyline
    +123
    -131
    STL
    SD
  • Best Total
    -105
    -110
    Over7.5
    7.5Under

Starting Pitchers

Miles Mikolas pitched six innings and allowed three earned runs in St. Louis’ 3-2 loss to the Cincinnati Reds last Thursday night. Mikolas has compiled an 11-12 record, a 3.46 ERA and a 1.05 WHIP in 187.1 innings pitched this season.

Blake Snell held the Arizona Diamondbacks to only one earned run and collected seven strikeouts across seven innings in a 12-3 Padres victory last Friday night. Snell has allowed one run or none in 10 of his last 14 starts and owns a 3.85 ERA and a 1.29 WHIP in 2022.

San Diego’s Pitching Has Been Dominant During Win Streak

Mike Clevinger and three Padres relievers combined to twirl a 5-0 shutout of the Cardinals on Tuesday night. San Diego’s pitching staff has now allowed only one earned run in the team’s last three games combined. The Padres have outscored opponents 25-4 during their current 4-0 winning streak.

Juan Soto has also been a major contributor during this winning streak. After collecting only one hit in his previous nine games, Soto has gone 7-for-15 (.467) with three runs and six RBIs in San Diego’s last four games.

St. Louis Offense Has Gone Ice-Cold

The Cardinals rank fourth in the majors in run production this season, averaging 4.79 runs per game. But over their last three games, the Cardinals have scored only one run, and they’ve suffered back-to-back shutout losses to Cincinnati and San Diego this week.

Paul Goldschmidt has gone 2-for-12 (.166) over St. Louis’ last three games and is batting just .241 in September. Despite his recent cold streak, Goldschmidt still has a .322 batting average heading into Wednesday’s game against the Padres.

Cardinals Player Prop: Miles Mikolas UNDER 3.5 Strikeouts (-110)

Miles Mikolas has struck out four or fewer batters in nine of his last 12 games and exactly three batters in four of his last five games. Facing a solid Padres lineup on Wednesday, this will likely be another spot where Mikolas fails to eclipse three strikeouts.

Padres Player Prop: Blake Snell OVER 6.5 Strikeouts (+102)

Blake Snell has been racking up strikeouts over the last few months, recording at least seven strikeouts in eight of his last 10 starts. With St. Louis’ offense slumping this week, look for Snell’s dominance to continue in this one.

Cardinals: Keys To Victory

St. Louis has to get some offense going. This may be easier said than done against a red-hot Padres starting staff and bullpen, but the Cardinals are due for a breakthrough on offense and that could lead to a Cardinals vs Padres prediction win if it comes on Wednesday.

Padres: Keys To Victory

With Juan Soto hitting well and the team pitching well, the Padres appear to be rounding into postseason form down the stretch. More of the same on Wednesday night should help San Diego get the job done as a Cardinals vs Padres pick at home.

MLB Computer Pick: Cardinals +1.5

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Shark Bites
  • St. Louis is 25-11 in its last 36 games.
  • San Diego is 6-0 in its last 6 home games vs St. Louis.
  • The UNDER is 6-1 in St. Louis’ last 7 games.
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