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The defending champion Blue Devils are, not surprisingly, massive betting favorites when they host Miami-Ohio on Tuesday night in NCAA basketball action. But can they conquer the massive spread?

Duke is favored by 25.5 points at Bovada, Bovada and virtually every other major book. Then again, the Blue Devils were 23.5-point favorites in their opener against Princeton and won that game by 37 points.

The Blue Devils “only” have Kyle Singler and Nolan Smith back from last year’s championship starting five but, if their first game was any indication, that’s just fine. Smith led the team with 22 points on 10 of 15 shooting while Singler was 7 of 10 for 16 points.

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In total, five different Duke players scored at least 13 points. Kyrie Irving made his presence felt with 17 points and a team-high nine assists.

Miami-Ohio won its season opener but it wasn’t in convincing fashion. The RedHawks were favored by 10 points at home against Towson but scraped by with a 60-57 win, failing to cover. On the road against Duke, the RedHawks could be in big trouble. Bettors may want to pounce on the champs to cover the 25.5 points.

No. 12 Gonzaga puts its 2-0 record on the line against San Diego State at 11:00 p.m. ET on Tuesday night. The hosting Bulldogs are 4.5-point favorites at each major book, including Sportsbook.ag and Bovada.

Gonzaga has started in style. It crushed Southern 117-72 in its season opener and powered through Indiana-Purdue 85-56 in its second game. The first game had no spread at major books but Gonzaga covered the 16 points in the win over Indiana-Purdue.

Steven Gray has been a force for Gonzaga early on, leading the team in points (21.0), assists (8.5), rebounds (7.5), steals (3.5) and even blocks (0.5) per game so far. Bettors should expect more strong efforts from Gray, who has improved his scoring average in all four of his NCAA seasons to date.

San Diego State is no pushover, however, ranked 25th in the country. It won 25 games last year and returns all five starters from that team. San Diego State impressed in its opener, beating Long Beach State 81-65 and covering the six-point spread. Kawhi Leonard was a force for the Aztecs, totalling 21 points and 12 rebounds. D.J. Gay also chipped in 20 points.

As impressive as San Diego State looks, should bettors take a chance on the Aztecs this early in the season? Not so fast. It’s not like the spread is 10 points. Gonzaga is only favored by 4.5 points at home; that doesn’t seem like a huge number to cover.