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Saint Louis vs. Louisville Betting Odds

It'll be a No. 4 seed vs. a No. 5 seed in Midwest Region action at the NCAA Tournament on Saturday as the Louisville Cardinals hit the hardwood against the Saint Louis Billikins - who are just 1-8-1 ATS in their past 10 games.

Louisville topped Manhattan 71-64 in their March Madness opener on Thursday night to advance to the Round of 32, while Saint Louis edged N.C. State 83-80 in their Thursday game.

No. 4 seed Louisville was getting a lot of respect from oddsmakers at Bovada, who had them at -9. The total was low at 133 over at TopBet


Interestingly, 4 seeds enjoy a 6-1 ATS run vs 5 seeds since 2010. Saint Louis is just 1-8-1 ATS in its past 10 games overall. Meanwhile, Louisville is 4-1 ATS when favored in the second round since 1996.

Odds Shark computer pick - 72.8-61.6 Cardinals

Supporters of the Billikens have watched them go 27-6 and 10-19-1 ATS on the year, while the Cardinals are at 30-5 and 19-14 ATS. In totals betting, the Cardinals are 15-17, while the Billikens have a 11-19 mark.

View Saint Louis Billikens vs Louisville Cardinals Odds and Stats.

The power rankings show a disparity between these teams, with the Cardinals rated this week at No. 1 and the Billikens sitting at No. 169.

Saint Louis was an 83-80 winner in their most recent outing at home against North Carolina State. They earned a push of the 3-point spread as favorites. The Billikens got a 22-point performance from Rob Loe, who added 15 rebounds, as Saint Louis ran past North Carolina State 83-80 on Thursday at Amway Center.

In their last action, Louisville was a 71-64 winner at home against Manhattan. They failed to cover the 16-point spread as favorites. Russ Smith scored 18 points leading the Cardinals to a 71-64 victory over Manhattan at Amway Center on Thursday.

How They Match Up:
Offensively, the game matches up Louisville's No. 8 nationally ranked offense (81.8 points per game) against a Billikens defense that sits as the No. 16 at 61.79 PPG. The Cardinals have been averaging 47.09% from the field, more than the Billikens have managed so far this season (44.49% on average).

A few Billikens at Cardinals trends to consider:
Saint Louis is 1-8-1 ATS in its last 10 games
Saint Louis is 21-4 SU in its last 25 games
Saint Louis is 2-4 SU in its last 6 games
Saint Louis is 6-2 ATS in its last 8 games when playing Louisville
Louisville is 5-1 ATS in its last 6 games
Louisville is 5-0 SU in its last 5 games
The total has gone UNDER in 4 of Louisville's last 5 games
Louisville is 2-7-1 ATS in its last 10 games when playing Saint Louis