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The Arizona Wildcats are favored for March Madness South region odds.

It was a bloodbath on the opening night of the Sweet 16 as two No. 1 seeds got bounced from the tournament, including the favorites in the March Madness South Region odds, the Arizona Wildcats.

See which team Joe Fortenbaugh is picking in his South Region best bet:

The Wildcats had odds of +135 to win the South Region before their 72-60 defeat at the hands of the fifth-seeded Houston Cougars. As a result, the Cougars are now favored to claim the South as they are the slight betting favorites in their Elite Eight matchup with No. 2 Villanova.

Online sportsbook Bovada has updated South Region odds for the final game of the region and has Houston as a -135 favorite over Villanova (+115). If you’re looking to bet on the point spread for a little extra betting value, the Cougars are 2-point favorites. See the full Cougars vs Villanova preview along with a computer pick for the game.

March Madness Betting Sites

Who Will Win The March Madness South Region?

March Madness South Region Odds
Team Odds
Houston Cougars -135
Villanova Wildcats +115

Odds as of March 25 at Bovada

Arizona Falls In Sweet 16 

The Arizona Wildcats may have been the most consistent team in all of college basketball through the season, demonstrating they could score with anyone in the country and holding their own defensively.

They showed this well-rounded play with a strong 87-70 triumph over Wright State in the Round of 64. The Wildcats had a scare in the second round, needing overtime to sneak past a pesky No. 9 TCU squad. 

The narrow overtime victory may have been a foreshadowing of what was to come next as the Wildcats couldn’t penetrate Houston’s defense, resulting in a Sweet 16 exit on Thursday night. 

Cougars vs Wildcats: Who’s Going To The Final Four?

The old adage that defense wins championships appears to ring true for both the Cougars and Villanova Wildcats, who’ve surrendered fewer than 70 points in each of their three games on the road to the Elite Eight.

In fact, Houston ranked third in the nation by allowing 59 points per game all season and Villanova wasn’t far behind, in a tie for 20th allowing 62.7 points per game. Perhaps the UNDER 128.5 could be a worthwhile wager on Saturday. 

It had been 37 years between Final Four appearances for Houston, which hadn’t made it that deep into March Madness since 1984 before qualifying last season. Meanwhile, ’Nova hasn’t advanced beyond the Elite Eight since 2018 when the Wildcats went on to win the whole tournament. Their odds to win March Madness are now +650 so there’s some value if you believe they can knock off the Cougars and continue that trend.

While the Wildcats are the higher seed, they are the betting underdog in this matchup and I believe that speaks to the Cougars’ impressive win over Arizona while shutting down that offense, and I think Houston will continue its winning ways into the Final Four.

March Madness South Region Historical Betting Records & Information

If you’re the type of bettor who loves to look at historical results to help with your March Madness handicapping, you’re not alone. It shouldn’t be used as a sole reason to make a bet but it’s hard to predict the future without knowing your history.

Here’s a look at the March Madness South Region results since the 2010 season:

March Madness South Region Betting History
Season No. 1 Seed South Region Winner (Seed)
2021 Baylor Baylor (#1)
2019 Virginia Virginia (#1)
2018 Virginia Loyola Chicago (#11)
2017 North Carolina North Carolina (#1)
2016 Kansas Villanova (#2)
2015 Duke Duke (#1)
2014 Florida Florida (#1)
2013 Kansas Michigan (#4)
2012 Kentucky Kentucky (#1)
2011 Kansas VCU (#11)
2010 Duke Duke (#1)

March Madness Betting Sites


March Madness South Region Odds FAQ

Where can I bet on the odds to win the South Region for March Madness?

Like most college basketball futures, you can bet on the winner of the South Region for March Madness at most popular online sportsbooks. Odds Shark’s experts have compiled and reviewed a list of the best March Madness Betting Sites to help you find the best site to place your wager and win.

How should I bet on the South odds for March Madness?

If you are looking to place a futures bet on the winner of the South Region, you should take into consideration both the chances a team has to win and their potential odds value. Odds Shark’s How to Bet on March Madness guide has in-depth strategies and tips on how to successfully bet on the NCAAB Tournament this year.

Who has the best odds to win the South Region for March Madness?

The Houston Cougars have the best odds to win the South Region in March Madness. After the favored Arizona Wildcats were knocked out in the Sweet 16, the Cougars are now seen by oddsmakers as the 2022 college basketball team with the best chance to make it out of the South Region and progress to the Final Four.