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Cardinals Host Clemson in Crucial ACC Matchup

The Louisville Cardinals face a crucial test on Saturday, when they open their home schedule with a visit from the defending national champion Clemson Tigers. The Cardinals have buried a three-game SU slide with a pair of season-opening wins, while the Tigers allowed just nine total points over two home victories to open their campaign.

Shark Bites
  • The total has gone OVER in five of Louisville’s last six games in September.
  • Louisville is 7-1 ATS in its last eight games in Week 3.
  • The total has gone OVER in six of Clemson’s last eight games.

The Cardinals have won seven straight SU at home against ACC rivals, but have been a general betting disappointment, going 4-7 ATS in 11 conference matchups, and 2-8-1 ATS in their past 11 games overall.

The Tigers have yet to surrender a touchdown in SU and ATS wins over Kent State and Auburn to start their national title defense. Clemson has now allowed seven or fewer points in four of six games, but has given up 22.6 points per game over its past five away from Memorial Stadium, with the point total finishing OVER in four of those outings.

Clemson is also unbeaten in three meetings with the Cardinals since they joined the ACC in 2014, including a 20-17 win as 5-point chalk in its last visit to Papa John’s Cardinal Stadium two years ago.

Opening Odds & Computer Pick

The home Louisville Cardinals were 3-point underdogs in this NCAA football battle at Bovada earlier (watch for line movement). No OVER/UNDER line was available early in the week, but was set to be posted shortly.

OddsShark college football prediction models picked a 41-32 result in favor of the Tigers on Saturday. Check the matchup report for any updates or pick revisions before kickoff. View the computer score prediction and who will win the pick on the moneyline for all upcoming NCAAF matchups here.

Clemson Tigers vs Louisville Cardinals Matchup

Team Betting Records & Power Rankings

The Clemson Tigers will look to cover ATS vs their hosts on Saturday, as they are 2-0 ATS versus the spread this season, while the Louisville Cardinals are 0-1-1 ATS. Clemson is 1-1 against the OVER/UNDER total, while Louisville is 1-1 versus the number. Stay Informed: follow us on Twitter for odds specials, betting line moves and Louisville vs Clemson injuries news.

The game pits the Louisville Cardinals, currently No. 23 in our OddsShark NCAA Football Power Rankings, against the Clemson Tigers, who rate No. 1 in the latest survey.

Recent Outings Betting Recap

The Tigers grabbed a Week 2 victory over the Tigers in their last game, winning 14-6 at Memorial Stadium-Clemson.

In Louisville's last outing, Lamar Jackson threw for 393 yards to lead the Cardinals over North Carolina 47-35 at Kenan Stadium.

Betting Trends
  • Clemson is 5-1 ATS in its last 6 games
  • Clemson is 5-0 SU in its last 5 games
  • The total has gone OVER in 6 of Clemson's last 8 games
  • Clemson is 5-0 SU in its last 5 games on the road
  • Louisville is 0-4-1 ATS in its last 5 games
  • Louisville is 17-5 SU in its last 22 games
  • The total has gone UNDER in 4 of Louisville's last 6 games
  • Louisville is 1-4 ATS in its last 5 games at home

Next Betting Matchups

Clemson home to Boston College, Saturday, September 23
Louisville home to Kent State, Saturday, September 23