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Clemson 5-1 ATS on Road in September

The Clemson Tigers are 5-1 ATS in their last six games on the road in September as they travel to Louisville to take on the Cardinals in their first ACC conference matchup of the season on Thursday night.

Louisville meanwhile has struggled badly in the role of home underdog, losing eight of nine SU and ATS.

Shark Bites
  • The total has gone UNDER in five of Clemson’s past six games.
  • Louisville is 0-5 ATS in its past five games at home.
  • Clemson QB Deshaun Watson has thrown seven TDs and one INT in his past three starts.

Clemson strengthened its bid for a place in the Top 10 of the AP Top 25 with dominating wins over Wofford and Appalachian State to open the season, extending their ATS win streak to four games, but are winless ATS in their last five against ACC conference rivals.

The Cardinals face Clemson still searching for their first SU win of the season after coming up short 31-24 against Auburn in Week 1 before getting shocked 34-31 by the Houston Cougars on the weekend in their home opener as 13.5-point favorites.

Louisville remains a solid 10-1 SU in their last 11 games against ACC opponents, but has failed to cover in their last three games.

Opening Odds & Computer Pick

Betting fans backing the Louisville Cardinals here saw them at Bovada as 6.5-point underdogs in this college football clash. The total was 52 earlier Thursday over at TopBet.

Odds Shark score prediction models pick a 22-20 result in favor of the Tigers on Thursday. View the computer score prediction and who will win the pick on the moneyline for all upcoming NCAAF matchups here.

Clemson Tigers vs Louisville Cardinals Matchup

Team Betting Records & Power Rankings

Louisville battles the Clemson Tigers, currently with a 2-0 mark (2-0 ATS). The over under records, important for totals betting, are 2-0 for the Cardinals and 1-1 for the Clemson Tigers. Stay Informed: follow us on Twitter for odds specials, betting line moves and Louisville vs Clemson injuries news.

It's a betting matchup between the No. 51-rated Louisville Cardinals and the No. 11-ranked Clemson Tigers, according to the NCAA College Football Power Rankings here at Odds Shark.

Recent Outings Betting Recap

In their last game, Clemson got a 104-yard performance from Marcus Cox as a key part of its 41-10 win over Appalachian State.

Micky Crum hauled in 6 passes for 103 yards against the Houston defense in the team's last game, but the result was a 34-31 loss against the Cougars on Saturday.

Betting Trends
  • Clemson is 4-1 ATS in its last 5 games
  • Clemson is 5-0 SU in its last 5 games
  • The total has gone UNDER in 5 of Clemson's last 6 games
  • Clemson is 2-4 ATS in its last 6 games on the road
  • Louisville is 18-7 SU in its last 25 games
  • The total has gone OVER in 6 of Louisville's last 7 games
  • Louisville is 0-5 ATS in its last 5 games at home
  • Louisville is 18-4 SU in its last 22 games at home

Next Betting Matchups

Clemson home to Notre Dame, Saturday, October 3rd
Louisville home to Samford, Saturday, September 26th