College Football Week 2 Opening Lines

The USC Trojans have designs on getting back into the national title picture, and they'll get a great chance to assert themselves this week when they take on the Cardinal at Stanford as road underdogs on the college football Week 2 Sportsbook betting lines.

USC opened its season last week with a 52-13 thumping of Fresno State, while Stanford blanked UC Davis 45-0 in its first game of the season. For their matchup on Saturday afternoon at Stanford the oddsmakers at Sportsbook have opened the Cardinal as 3.5-point home favorites on the betting lines.

The other top matchup on the college football betting slate for Week 2 features another Pac-12 team, as Oregon plays host to Michigan State as a 12.5-point favorite on the college football Sportsbook betting lines at Sportsbook. Oregon beat South Dakota 62-13 in its first game of the season, while Michigan State topped Jacksonville State 45-7.

Matchup Reports: USC vs. Stanford | Michigan State vs. Oregon | Virginia Tech vs. Ohio State

Ohio State survived its first game without quarterback Braxton Miller at the helm last week, beating Navy by a score of 34-17. The Buckeyes are listed as 12-point favorites on the Week 2 college football Sportsbook betting lines at Sportsbook over Virginia Tech, who are coming off a 34-9 win over William & Mary.

And two other top-ranked teams will get even bigger spreads to try and cover this week, with Alabama favored by 40.5 points at home over Florida Atlantic on the Sportsbook odds at Sportsbook, and Oklahoma favored by 24.5 points on the road against Tulsa. No. 1 Florida State hosts Citadel this week; odds were not yet posted for that expected mismatch as of Sunday night.

College Football Week 2 Sportsbook Betting Lines at Sportsbook (Posted As Available)

THURSDAY, SEPTEMBER 4 8:00pm ET - Arizona at UTSA (+7)

FRIDAY, SEPTEMBER 5 7:00pm ET - Pittsburgh at Boston College (+4.5) 10:30pm ET - Washington State at Nevada (pick'em)

SATURDAY, SEPTEMBER 6 12:00pm ET - Florida Atlantic at Alabama (-40.5) 12:00pm ET - Oklahoma at Tulsa (+24.5) 12:00pm ET - Western Illinois at Wisconsin () 12:00pm ET - Kansas State at Iowa State (+12) 12:00pm ET - McNeese State at Nebraska () 12:00pm ET - Missouri at Toledo (+6) 12:00pm ET - Arkansas State at Tennessee () 12:00pm ET - Buffalo at Army (-3) 12:00pm ET - Stony Brook at Connecticut () 12:00pm ET - SMU at North Texas () 12:00pm ET - Western Kentucky at Illinois (-7) 12:00pm ET - Akron at Penn State (-16) 12:00pm ET - Central Michigan at Purdue (-2.5) 12:00pm ET - Howard at Rutgers () 12:30pm ET - South Carolina State at Clemson () 1:00pm ET - Navy at Temple (+4) 2:00pm ET - South Alabama at Kent State (pick'em) 2:00pm ET - UAB at Mississippi State (-29) 2:00pm ET - New Mexico State at Georgia State (-1.5) 3:00pm ET - Fresno State at Utah (-10) 3:00pm ET - Sacramento State at California () 3:00pm ET - Colorado at Massachusetts (+17) 3:05pm ET - Eastern Washington at Washington () 3:30pm ET - USC at Stanford (-3.5) 3:30pm ET - Eastern Kentucky at Miami-Ohio () 3:30pm ET - Virginia Military Institute at Bowling Green () 3:30pm ET - Ohio at Kentucky (-9.5) 3:30pm ET - Northern Illinois at Northwestern (-5.5) 3:30pm ET - Maryland at South Florida (+10) 3:30pm ET - Ball State at Iowa (-17) 3:30pm ET - Middle Tennessee at Minnesota (-17.5) 3:30pm ET - Missouri State at Oklahoma State () 3:30pm ET - Richmond at Virginia () 4:00pm ET - Georgia Tech at Tulane (+10.5) 4:00pm ET - Eastern Michigan at Florida (-37.5) 4:00pm ET - Nicholls State at Arkansas () 4:30pm ET - Ole Miss at Vanderbilt (+20) 6:00pm ET - Campbell at Appalachian State () 6:00pm ET - Old Dominion at North Carolina State (-16) 6:00pm ET - Wagner at Florida International () 6:00pm ET - Savannah State at Georgia Southern () 6:30pm ET - Michigan State at Oregon (-12.5) 6:30pm ET - Gardner-Webb at Wake Forest () 7:00pm ET - San Jose State at Auburn (-30) 7:00pm ET - East Carolina at South Carolina (-14) 7:00pm ET - Arizona State at New Mexico (+26.5) 7:00pm ET - Southeast Missouri State at Kansas () 7:00pm ET - Murray State at Louisville () 7:00pm ET - Florida A&M at Miami () 7:00pm ET - Duke at Troy (+18.5) 7:00pm ET - Louisiana Tech at Louisiana-Lafayette (-12.5) 7:00pm ET - Rhode Island at Marshall () 7:00pm ET - Alcorn State at Southern Miss () 7:00pm ET - Idaho at Louisiana-Monroe (-14) 7:30pm ET - Citadel at Florida State () 7:30pm ET - Northwestern State at Baylor () 7:30pm ET - Sam Houston State at LSU () 7:30pm ET - Michigan at Notre Dame (-4.5) 7:30pm ET - Lamar at Texas A&M () 7:30pm ET - BYU at Texas (-3.5) 7:30pm ET - Towson at West Virginia () 8:00pm ET - Virginia Tech at Ohio State (-12) 8:00pm ET - San Diego State at North Carolina (-15) 8:00pm ET - Grambling State at Houston () 8:00pm ET - Idaho State at Utah State () 10:00pm ET - Memphis at UCLA (-25) 10:00pm ET - Northern Colorado at UNLV () 10:15pm ET - Air Force at Wyoming (-1) 10:15pm ET - Colorado State at Boise State (-10.5) 10:30pm ET - Oregon State at Hawaii (+12.5) 11:00pm ET - Texas Tech at UTEP (+18.5)