College Football Week 4 Opening Lines

The Florida State Seminoles return from a one-week break to take on another ranked team this weekend, and the online sportsbooks have opened them as big favorites at home against the Clemson Tigers.

At Sportsbook the Seminoles opened as 20-point home favorites against the Tigers for Saturday, with Florida State at No. 1 and Clemson at No. 22 in this week's AP Top 25 poll. Florida State trounced Clemson 51-14 as a 4.5-point road favorite last season, but the Tigers are 7-2 ATS in the last nine games between the two teams.

(Editor's Note: On Wednesday afternoon Florida State Seminoles quarterback Jameis Winston was suspended for the first half of their game against the Clemson Tigers. On Friday night that suspension was extended to the entire game)

Matchup Reports: Auburn vs. Kansas State | Florida vs. Alabama | Clemson vs. Florida State

Elsewhere at the top of the polls, No. 2 Oregon opened as a 24.5-point road favorite at Sportsbook for their game against Washington State on Saturday, while No. 3 Alabama is a 16-point home favorite on the Sportsbook lines against Florida, and No. 4 Oklahoma opened as an 11-point road favorite against West Virginia at the sportsbook.

Texas A&M opened as a big 31-point road favorite against SMU for Saturday, while South Carolina is a 20.5-point road favorite against Vanderbilt. The Gamecocks are 5-0 SU in their last five games against the Commodores, but they've managed to cover the posted spread in just two of the last seven games between the two teams.

Finally, Auburn opened as a 9-point road favorite for their game against Kansas State on Thursday night, with the college football betting trends for the week pointing out that the Tigers are 4-0 ATS in their last four road games.

College Football Week 4 Sportsbook Betting Lines at Sportsbook (Posted As Available)

THURSDAY, SEPTEMBER 18 7:30pm ET - Auburn at Kansas State (+9)

FRIDAY, SEPTEMBER 19 8:00pm ET - Connecticut at South Florida (-2.5)

SATURDAY, SEPTEMBER 20 12:00pm ET - Troy at Georgia (-37.5) 12:00pm ET - Eastern Michigan at Michigan State (-45.5) 12:00pm ET - Georgia Tech at Virginia Tech (-7.5) 12:00pm ET - Bowling Green at Wisconsin (-21.5) 12:00pm ET - Iowa at Pittsburgh (-4.5) 12:00pm ET - Western Illinois at Northwestern () 12:00pm ET - Southern Illinois at Purdue () 12:00pm ET - Old Dominion at Rice (-10.5) 12:30pm ET - Maryland at Syracuse () 12:30pm ET - Tulane at Duke (-18) 1:00pm ET - Maine at Boston College () 1:00pm ET - Delaware State at Temple () 2:00pm ET - Hawaii at Colorado (-7) 2:00pm ET - Marshall at Akron () 3:30pm ET - Florida at  Alabama (-16) 3:30pm ET - Texas A&M at SMU (+31) 3:30pm ET - Louisville at Florida International (+26) 3:30pm ET - Virginia at BYU (-16) 3:30pm ET - Nicholls State at North Texas () 3:30pm ET - Norfolk State at Buffalo () 3:30pm ET - North Carolina at East Carolina (-2) 3:30pm ET - Army at Wake Forest (-2.5) 3:30pm ET - Central Michigan at Kansas () 3:30pm ET - Rutgers at Navy () 3:30pm ET - Utah at Michigan () 4:00pm ET - Indiana at Missouri () 4:00pm ET - Texas State at Illinois (-15) 4:00pm ET - Massachusetts at Penn State (-27.5) 4:00pm ET - San Jose State at Minnesota () 4:00pm ET - Florida Atlantic at Wyoming (-4) 6:00pm ET - Presbyterian at North Carolina State () 6:00pm ET - Bethune-Cookman at UCF () 6:00pm ET - Georgia State at Washington () 7:00pm ET - Mississippi State at LSU (-9) 7:00pm ET - Utah State at Arkansas State () 7:00pm ET - Northern Illinois at Arkansas (-12.5) 7:00pm ET - Miami-Ohio at Cincinnati (-30) 7:00pm ET - Middle Tennessee at Memphis (-7.5) 7:00pm ET - Northwestern State at Louisiana Tech () 7:00pm ET - Appalachian State at Southern Miss () 7:00pm ET - Ball State at Toledo () 7:00pm ET - Idaho at Ohio (-13) 7:00pm ET - Murray State at Western Michigan () 7:30pm ET - Oklahoma at West Virginia (+11) 7:30pm ET - South Carolina at Vanderbilt (+20.5) 7:30pm ET - Georgia Southern at South Alabama () 8:00pm ET - Clemson at Florida State (-20) 8:00pm ET - UNLV at Houston (-20) 8:00pm ET - New Mexico at New Mexico State () 8:00pm ET - Miami at Nebraska (-7.5) 10:00pm ET - California at Arizona (-12) 10:00pm ET - Southern Utah at Fresno State () 10:30pm ET - Oregon at Washington State (+24.5) 10:30pm ET - San Diego State at Oregon State (-10) 10:30pm ET - Louisiana-Lafayette at Boise State (-16.5)