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Oregon, ranked second, opened as a big 23-point favorite for its matchup against Arizona on Thursday night, and heading into kickoff that line had moved just slightly to Oregon -24 at the online sportsbooks.

The Wildcats will be looking for the road upset in that contest, and they're 6-3 ATS in their last nine games against the Ducks for their supporters on the college football odds. A victim of big spreads, Oregon is just 2-7 ATS in its last nine games.

Matchup Reports: Arizona vs. Oregon | Texas A&M vs. Miss State | SMU vs. East Carolina

On Saturday the focus will be on the six games between ranked teams on the college football slate, including No. 6 Texas A&M at No. 12 Mississippi State. The Bulldogs opened as just 1-point home favorites for that contest, but heading into the weekend that line had moved to Mississippi State -2.5.

No. 11 Ole Miss opened as a 5.5-point home underdog against No. 3 Alabama, with that line now Crimson Tide -7. No. 9 Notre Dame has moved from a 1-point underdog to a 2-point underdog at home against No. 14 Stanford, with No. 5 Auburn going from a 9-point favorite to just a 7.5-point favorite at home against No. 15 LSU.

No. 10 Michigan State opened at -8.5 at home against No. 19 Nebraska, with the Spartans now favored by just a touchdown. Finally, the game between No. 4 Oklahoma and No. 25 TCU has remained stable at Sooners -5 over the past few days. The Sooners are 4-1 ATS in their last five games as a road favorite according to the betting trends for the week.

And for those looking for a big spread for the weekend, No. 22 East Carolina has moved from a 36-point favorite to a 40.5-point favorite at home against SMU for Sunday. SMU is just 4-13 ATS in its last 17 games as a road underdog.

College Football Week 6 Betting Lines at 5Dimes

THURSDAY, OCTOBER 2 7:00pm ET - UCF at Houston (-3.5) (OPEN -2.5) 7:00pm ET - Florida Atlantic at Florida International (+6.5) (OPEN +9.5) 10:30pm ET - Arizona at Oregon (-24) (OPEN -23)

FRIDAY, OCTOBER 3 7:00pm ET - Louisville at Syracuse (+2.5) (OPEN +3.5) 10:00pm ET - San Diego State at Fresno State (-3) (OPEN +1) 10:15pm ET - Utah State at BYU (-21) (OPEN -21)

SATURDAY, OCTOBER 4 12:00pm ET - Marshall at Old Dominion (+17.5) (OPEN +18) 12:00pm ET - Iowa State at Oklahoma State (-17) (OPEN -17) 12:00pm ET - SMU at East Carolina (-40.5) (OPEN -36) 12:00pm ET - Texas A&M at Mississippi State (-2.5) (OPEN -1) 12:00pm ET - Ohio State at Maryland (+8.5) 12:00pm ET - Florida at Tennessee (-2.5) (OPEN +1) 12:00pm ET - Purdue at Illinois (-10.5) (OPEN -10.5) 12:00pm ET - Southern Miss at Middle Tennessee (-18) (OPEN -16.5) 12:00pm ET - Ball State at Army (-2.5) (OPEN -3) 12:30pm ET - Virginia Tech at North Carolina (+2) (OPEN +1) 2:00pm ET - Eastern Michigan at Akron (-23) (OPEN -21) 2:30pm ET - North Texas at Indiana (-13.5) (OPEN -14) 2:30pm ET - Massachusetts at Miami-Ohio (-3.5) (OPEN -4) 3:00pm ET - Tulsa at Colorado State (-14.5) (OPEN -14.5) 3:30pm ET - Arizona State at USC (-11.5) (OPEN -10.5) 3:30pm ET - Alabama at Ole Miss (+7) (OPEN +5.5) 3:30pm ET - Wake Forest at Florida State (-38) (OPEN -38) 3:30pm ET - Oklahoma at TCU (+5) (OPEN +5) 3:30pm ET - Baylor at Texas (+14.5) (OPEN +14.5) 3:30pm ET - Stanford at Notre Dame (+2) (OPEN +1) 3:30pm ET - Wisconsin at Northwestern (+8) (OPEN +9.5) 3:30pm ET - North Carolina State at Clemson (-14) (OPEN -14) 3:30pm ET - Buffalo at Bowling Green (-6) (OPEN -5.5) 3:30pm ET - Navy at Air Force (+4) (OPEN +4.5) 3:30pm ET - Ohio at Central Michigan (-4) (OPEN -5) 3:30pm ET - New Mexico at UTSA (-17) (OPEN -18.5) 4:00pm ET - Kansas at West Virginia (-26) (OPEN -24.5) 4:00pm ET - Vanderbilt at Georgia (-33.5) (OPEN -32) 4:00pm ET - Oregon State at Colorado (+6.5) (OPEN +7.5) 5:00pm ET - Kent State at Northern Illinois (-24.5) (OPEN -23) 6:00pm ET - South Alabama at Appalachian State (+3.5) (OPEN +5.5) 7:00pm ET - Utah at UCLA (-13.5) (OPEN -12.5) 7:00pm ET - Memphis at Cincinnati (-4) (OPEN -6) 7:00pm ET - LSU at Auburn (-7.5) (OPEN -9) 7:00pm ET - Texas Tech at Kansas State (-12.5) 7:00pm ET - Louisiana-Monroe at Arkansas State (-11) (OPEN -10) 7:00pm ET - Georgia State at Louisiana-Lafayette (-17) (OPEN -17) 7:00pm ET - Idaho at Texas State (-17) (OPEN -14.5) 7:00pm ET - Hawaii at Rice (-7) (OPEN -6) 7:00pm ET - Toledo at Western Michigan (+5) (OPEN +9) 7:00pm ET - Michigan at Rutgers (-2.5) (OPEN -4) 7:00pm ET - UTEP at Louisiana Tech (-12) (OPEN -13.5) 7:00pm ET - UAB at Western Kentucky (-9) (OPEN -13.5) 7:30pm ET - South Carolina at Kentucky (+5) (OPEN +7) 7:30pm ET - Pittsburgh at Virginia (-6.5) (OPEN -4.5) 7:30pm ET - Miami at Georgia Tech (pick'em) (OPEN pick'em) 8:00pm ET - Nebraska at Michigan State (-7) (OPEN -8.5) 8:00pm ET - Georgia Southern at New Mexico State (+18) (OPEN +17) 8:00pm ET - UNLV at San Jose State (-10) 10:30pm ET - Boise State at Nevada (+3.5) (OPEN +2.5) 10:30pm ET - California at Washington State (-3) (OPEN -3.5)