College Football Week 6 Opening Lines

If the No. 1 Florida State Seminoles are going to pick up their first ATS victory of the season on Saturday afternoon they're going to have to do it as big home favorites on the Week 6 college football betting lines against Wake Forest.

The Seminoles opened as 38-point favorites against the Demon Deacons after getting tagged with ATS losses in their first four games of the season - all SU victories. Florida State has covered in four of its last five games against Wake Forest, and it's also 5-2 ATS in its last seven home games against fellow ACC schools.

Matchup Reports: WF vs. Florida State | Arizona vs. Oregon | Stanford vs. Notre Dame

No. 2 Oregon opened as a 23-point home favorite against Arizona for their matchup on Thursday night, with No. 3 Alabama a 5.5-point road favorite against No. 11 Ole Miss on Saturday afternoon, and No. 4 Oklahoma a 5-point road favorite against No. 25 TCU.

No. 5 Auburn hosts No. 15 LSU this weekend, and they're 9-point favorites on the Sportsbook Week 6 college football betting lines. Auburn is 7-1 ATS in its last eight home games, while LSU is 2-5-1 ATS in its last eight road games.

And in one of the biggest matchups of the weekend, No. 14 Stanford opened as a slim 1-point road favorite against No. 9 Notre Dame. The Fighting Irish are 3-0 ATS in their last three home games, but just 1-3 ATS in their last four home games against Pac-12 teams. The Cardinal have picked up three ATS wins in their last four games against the Irish.

College Football Week 6 Sportsbook Betting Lines at Sportsbook (Posted As Available)

THURSDAY, OCTOBER 2 7:00pm ET - UCF at Houston (-2.5) 7:00pm ET - Florida Atlantic at Florida International (+9.5) 10:30pm ET - Arizona at Oregon (-23)

FRIDAY, OCTOBER 3 7:00pm ET - Louisville at Syracuse (+3.5) 10:00pm ET - San Diego State at Fresno State (+1) 10:15pm ET - Utah State at BYU (-21)

SATURDAY, OCTOBER 4 12:00pm ET - Marshall at Old Dominion (+18) 12:00pm ET - Iowa State at Oklahoma State (-17) 12:00pm ET - SMU at East Carolina (-36) 12:00pm ET - Texas A&M at Mississippi State (-1) 12:00pm ET - Ohio State at Maryland () 12:00pm ET - Florida at Tennessee (+1) 12:00pm ET - Purdue at Illinois (-10.5) 12:00pm ET - Southern Miss at Middle Tennessee (-16.5) 12:00pm ET - Ball State at Army (-3) 12:30pm ET - Virginia Tech at North Carolina (+1) 2:00pm ET - Eastern Michigan at Akron (-21) 2:30pm ET - North Texas at Indiana (-14) 2:30pm ET - Massachusetts at Miami-Ohio (-4) 3:00pm ET - Tulsa at Colorado State (-14.5) 3:30pm ET - Arizona State at USC (-10.5) 3:30pm ET - Alabama at Ole Miss (+5.5) 3:30pm ET - Wake Forest at Florida State (-38) 3:30pm ET - Oklahoma at TCU (+5) 3:30pm ET - Baylor at Texas (+14.5) 3:30pm ET - Stanford at Notre Dame (+1) 3:30pm ET - Wisconsin at Northwestern (+9.5) 3:30pm ET - North Carolina State at Clemson (-14) 3:30pm ET - Buffalo at Bowling Green (-5.5) 3:30pm ET - Navy at Air Force (+4.5) 3:30pm ET - Ohio at Central Michigan (-5) 3:30pm ET - New Mexico at UTSA (-18.5) 4:00pm ET - Kansas at West Virginia (-24.5) 4:00pm ET - Vanderbilt at Georgia (-32) 4:00pm ET - Oregon State at Colorado (+7.5) 5:00pm ET - Kent State at Northern Illinois (-23) 6:00pm ET - South Alabama at Appalachian State (+5.5) 7:00pm ET - Utah at UCLA (-12.5) 7:00pm ET - Memphis at Cincinnati (-6) 7:00pm ET - LSU at Auburn (-9) 7:00pm ET - Texas Tech at Kansas State () 7:00pm ET - Louisiana-Monroe at Arkansas State (-10) 7:00pm ET - Georgia State at Louisiana-Lafayette (-17) 7:00pm ET - Idaho at Texas State (-14.5) 7:00pm ET - Hawaii at Rice (-6) 7:00pm ET - Toledo at Western Michigan (+9) 7:00pm ET - Michigan at Rutgers (-4) 7:00pm ET - UTEP at Louisiana Tech (-13.5) 7:00pm ET - UAB at Western Kentucky (-13.5) 7:30pm ET - South Carolina at Kentucky (+7) 7:30pm ET - Pittsburgh at Virginia (-4.5) 7:30pm ET - Miami at Georgia Tech (pick'em) 8:00pm ET - Nebraska at Michigan State (-8.5) 8:00pm ET - Georgia Southern at New Mexico State (+17) 8:00pm ET - UNLV at San Jose State () 10:30pm ET - Boise State at Nevada (+2.5) 10:30pm ET - California at Washington State (-3.5)