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Oklahoma Sooners Prediction vs Iowa State Cyclones in Week 10 College Football Odds

Getting a win and covering the posted spread will be the goals for the Iowa State Cyclones on Saturday when they take on the Oklahoma Sooners at Memorial Stadium in Week 10 action.

Opening Odds & Computer Pick

Betting fans looking to back the visiting Iowa State Cyclones in this one found them as 26-point underdogs on the opening college football point spread at TopBet. Bookmark the college football odds pages to see where the over under number opens in this game.

Odds Shark computer prediction handicapping models run on this game pick a 46-18 victory for the Sooners. View the computer score prediction and who will win the pick on the moneyline for all upcoming NCAAF matchups here.

Iowa State Cyclones vs Oklahoma Sooners Matchup

Team Betting Records & Power Rankings

The Oklahoma Sooners sit at 7-1 (6-2 ATS) on the season; in comparison, the Iowa State Cyclones are currently 3-5 (4-4 ATS). Looking to bet on the totals? Oklahoma is 5-3 OU, and Iowa State is 1-7 OU. Stay Informed: follow us on Twitter for odds specials, betting line moves and Oklahoma vs Iowa State injuries news.

The OddsShark Power Rankings have the Oklahoma Sooners at No. 6 and the Iowa State Cyclones at No. 101 heading into this contest.

Statistical Matchup

The game also pits Oklahoma's No. 6-ranked offense, averaging 45.62 PPG, against a Iowa State defense that ranks No. 88 this week at 29.62 PPG. The Oklahoma aerial game is averaging 329.62 yards per game, more than the Iowa State Cyclones secondary allows through the air, 254 YPG per game.

In comparing defenses, the Iowa State Cyclones own the league's No. 110-rated front 7 in terms of stopping the run, allowing 236 yards per game when on the road. Oklahoma, on the other hand, rates No. 32 this week in generating rushing yards at home.

Recent Outings Betting Recap

Texas failed to break through the Iowa State defense in its last game, suffering a 24-0 shutout at the hands of the Cyclones in Week 9 action.

Baker Mayfield's 383-yard performance through the air was enough last time out, as Oklahoma earned a 62-7 win over Kansas on Saturday at Memorial Stadium.

Betting Trends
  • Iowa State is 4-9 ATS in its last 13 games
  • Iowa State is 3-11 SU in its last 14 games
  • The total has gone UNDER in 11 of Iowa State's last 12 games
  • Iowa State is 1-4 ATS in its last 5 games on the road
  • Oklahoma is 4-1 ATS in its last 5 games
  • Oklahoma is 7-1 SU in its last 8 games
  • The total has gone OVER in 5 of Oklahoma's last 6 games
  • Oklahoma is 4-1 SU in its last 5 games at home

Next Betting Matchups

Iowa State home to Oklahoma State, Saturday, November 14th
Oklahoma at Baylor, Saturday, November 14th