Iowa State Cyclones vs Oklahoma Sooners Week 6 Betting Prediction and Odds

Oklahoma looks to cover the Sooners-Cyclones point spread this week and improve its overall 4-0 mark when they host Iowa State in Week 6 action.

Sportsbook Odds & Computer Pick

The Oklahoma Sooners were sitting as -26-point favorites earlier in the week at Sportsbook. The total was to be set a bit later in the week for over under betting purposes.

Odds Shark computer score prediction models picked a possible 55-22 win for the Sooners early in the week. That score may change during the week, if injury or weather factors alter the numbers, so check the college football picks page before game time. View the computer score prediction and who will win the pick on the moneyline for all upcoming NCAAF matchups here.

Iowa State Cyclones vs Oklahoma Sooners Matchup

Team Betting Records & Power Rankings

The Iowa State Cyclones will look to cover ATS vs their hosts on Saturday, as they are 2-1-1 ATS versus the spread this season, while the Oklahoma Sooners are 3-1 ATS. Iowa State is 2-2 against the over under total, while Oklahoma is 2-1-1 versus the number. Stay Informed: follow us on Twitter for odds specials, betting line moves and Oklahoma vs Iowa State injuries news.

According to the Power Rankings here at Odds Shark it's the No. 5-rated Oklahoma Sooners and the No. 59-rated Iowa State Cyclones in this matchup.

Statistical Matchup

The game also pits Oklahoma's No. 4-ranked offense, averaging 48 PPG, against a Iowa State defense that ranks No. 59 this week at 24.75 PPG. The Oklahoma aerial game is averaging 399.75 yards per game, more than the Iowa State Cyclones secondary allows through the air, 264 YPG per game.

In comparing defenses, the Iowa State Cyclones own the league's No. 6-rated front 7 in terms of stopping the run, allowing 38 yards per game when on the road. Oklahoma, on the other hand, rates No. 62 this week in generating rushing yards at home.