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Louisville Cardinals at Pittsburgh Panthers Week 12 Betting Pick and Odds

The NCAA college football betting menu features a clash between Pittsburgh and Louisville on Saturday, with the host Panthers trying to win both for fans supporting them and bettors backing them.

Opening Odds & Computer Pick

Those siding with the visitors in this one saw the $Louisville Cardinals listed as 1.5-point underdogs earlier this week at Bovada. Meanwhile, the over under betting line was unavailable earlier in the week, but posted shortly at MyBookie.

Handicapping models based on recent betting stats and prediction formulas pick a 30-26 win for the Cardinals. View the computer score prediction and who will win the pick on the moneyline for all upcoming NCAAF matchups here.

Louisville Cardinals vs Pittsburgh Panthers Matchup

Team Betting Records & Power Rankings

Pittsburgh will face the 6-4 Louisville Cardinals, who own a 5-5 ATS mark on the season. In totals betting, the Pittsburgh Panthers are 4-5-1 so far this season while the Cardinals are 5-5. Stay Informed: follow us on Twitter for odds specials, betting line moves and Pittsburgh vs Louisville injuries news.

The power rankings show a disparity between these teams, with the Pittsburgh Panthers rated this week at No. 58 and the Louisville Cardinals sitting at No. 65.

Statistical Matchup

Offensively, the game matches up the Pittsburgh Panthers No. 83-ranked offense (27 PPG) against a Louisville Cardinals defense that ranks No. 35 at 22.3 PPG. The Pittsburgh Panthers passing attack has averaged 196.7 yards per game, less than the Louisville Cardinals give up through the air (202.5 YPG on average).

Defensively, the Louisville Cardinals feature the league's No. 8-rated road run defense, allowing 102 yards per game. Pittsburgh, meanwhile, ranks No. 49 in rushing offense at home.

Recent Outings Betting Recap

Last time out for the the Cavaliers, they were scorched by Canaan Severin for 116 receiving yards against the Cardinals in a 38-31 loss at Papa John's Cardinal Stadium.

Qadree Ollison tore up the turf for 111 rushing yards in the latest Panthers game, a 31-13 win over the Blue Devils at Wallace Wade Stadium.

Betting Trends
  • Louisville is 1-4 ATS in its last 5 games
  • Louisville is 6-1 SU in its last 7 games
  • Louisville is 7-3 ATS in its last 10 games on the road
  • Louisville is 16-6 SU in its last 22 games on the road
  • Pittsburgh is 2-4 ATS in its last 6 games
  • Pittsburgh is 5-2 SU in its last 7 games
  • Pittsburgh is 1-6 ATS in its last 7 games at home
  • Pittsburgh is 5-1 ATS in its last 6 games when playing Louisville

Next Betting Matchups

Louisville at Kentucky, Saturday, November 28th
Pittsburgh home to Miami, Friday, November 27th