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For the second straight week in college football, suspensions dominated the news late in the week. Key players will be out of two of this weekend’s biggest games.

Here’s a look at those suspensions as well as some other noteworthy news and betting angles in college football this Saturday.

LSU suspends three players

Starting running back Spencer Ware, star cornerback Tyrann Mathieu, and backup cornerback Tharold Simon are all suspended for this week’s game against No. 19 Auburn. As a 21-point favorite at home at TopBet, LSU should still win this game outright; but losing the leader of the defense and their main tailback could make Auburn more enticing with the points.

Michigan State’s William Gholston suspended

As if slowing down the highest scoring offense in college football going up against No. 4 Wisconsin this week wasn’t hard enough, Michigan State will now have to do so without their starting defensive end William Gholston. Gholston leads the team with seven tackles for loss, and has 20 tackles total this season. Wisconsin is an 8-point favorite on the road this week at [custom:bodog-link].

Oregon’s Darron Thomas and LaMichael James considered doubtful against Colorado

Both Darron Thomas and LaMichael James said this week that they would be available for this week’s game against Colorado, but Coach Chip Kelly hasn’t revealed his plans yet. Currently a 31-point road favorite at 5Dimes, Oregon is in little danger of losing this game even without its two stars, leading most to believe Kelly will rest them both. Redshirt freshman quarterback Bryan Bennett would make his first career start on the road if Thomas doesn’t play.

Wake Forest a popular bet against Duke

Just one week after playing a Florida State team that Duke had lost 16 straight games against, the Blue Devils take on another team they have trouble beating; Wake Forest. Wake Forest has won 11 straight over Duke and has covered the spread in each of their last two meetings. This stat, along with Wake Forest’s hot 4-2 SU and ATS start, made Wake Forest -3.5 the most popular game among OddsShark betting matchups with 73% of bettors expecting the Demon Deacons to cover.