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Orange visit Louisville Cardinals in Week 12 College Football Betting Clash

Syracuse travels to Louisville on Saturday, hoping to boost its 4-6 mark in Week 12 action with a victory over the Cardinals.

Opening Odds & Computer Pick

Odds makers at Bovada had the Louisville Cardinals as -11.5-point favorites in the matchup, while the betting total had not been set at press time (check BetOnline for the latest on the over under).

Odds Shark computer score prediction models picked a possible 43-27 win for the Cardinals early in the week. That score may change during the week, if injury or weather factors alter the numbers, so check the college football picks page before game time. View the computer score prediction and who will win the pick on the moneyline for all upcoming NCAAF matchups here.

Syracuse Orange vs Louisville Cardinals Matchup

Team Betting Records & Power Rankings

Louisville will face the 4-6 Syracuse Orange, who own a 6-3-1 ATS mark on the season. In totals betting, the Louisville Cardinals are 6-4 so far this season while the Orange are 3-7. Stay Informed: follow us on Twitter for odds specials, betting line moves and Louisville vs Syracuse injuries news.

This game matches up the No. 27 (Louisville Cardinals) and the No. 78 (Syracuse Orange) teams in the league, according to our current NCAA football Power Rankings at Odds Shark.

Statistical Matchup

The game also pits Louisville's No. 21-ranked offense, averaging 36.8 PPG, against a Syracuse defense that ranks No. 80 this week at 28.8 PPG. The Louisville aerial game is averaging 319.5 yards per game, more than the Syracuse Orange secondary allows through the air, 240.4 YPG per game.

In comparing defenses, the Syracuse Orange own the league's No. 81-rated front 7 in terms of stopping the run, allowing 187.5 yards per game when on the road. Louisville, on the other hand, rates No. 27 this week in generating rushing yards at home.

Recent Outings Betting Recap

Zack Mahoney led the way last time out for the Orange, connecting for 384 passing yards, but failing to earn the victory in a 64-43 loss to the Orange at Carrier Dome.

Lamar Jackson ran through the Virginia defense for 147 yards in Louisville's last game, handing the Cavaliers a 38-21 setback on Saturday at Papa John's Cardinal Stadium.

Betting Trends
  • Syracuse is 6-1-1 ATS in its last 8 games
  • Syracuse is 2-5 SU in its last 7 games
  • The total has gone UNDER in 13 of Syracuse's last 17 games
  • Syracuse is 5-0 ATS in its last 5 games on the road
  • Louisville is 2-11-1 ATS in its last 14 games
  • Louisville is 17-8 SU in its last 25 games
  • Louisville is 1-7 ATS in its last 8 games at home
  • Louisville is 13-4 SU in its last 17 games at home

Next Betting Matchups

Syracuse home to Boston College, Saturday, November 25th
Louisville at Kentucky, Saturday, November 25th