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Syracuse Orange vs Louisville Cardinals Week 10 Betting Prediction and Odds

Louisville will look to improve on its 4-4 record this week when they host Syracuse in Week 10 action at Papa John's Cardinal Stadium on Saturday.

Opening Odds & Computer Pick

The home Louisville Cardinals were -12-point favorites in this NCAA football battle at Bovada earlier (watch for line movement). No over under line was available early in the week, but was set to be posted shortly.

Odds Shark score prediction models pick a 33-18 result in favor of the Cardinals on Saturday. View the computer score prediction and who will win the pick on the moneyline for all upcoming NCAAF matchups here.

Syracuse Orange vs Louisville Cardinals Matchup

Team Betting Records & Power Rankings

Louisville will face the 3-5 Syracuse Orange, who own a 5-3 ATS mark on the season. In totals betting, the Louisville Cardinals are 3-5 so far this season while the Orange are 7-1. Stay Informed: follow us on Twitter for odds specials, betting line moves and Louisville vs Syracuse injuries news.

According to the Power Rankings here at Odds Shark it's the No. 70-rated Louisville Cardinals and the No. 104-rated Syracuse Orange in this matchup.

Statistical Matchup

Offensively, the game matches up the Louisville Cardinals No. 95-ranked offense (24.38 PPG) against a Syracuse Orange defense that ranks No. 86 at 29.38 PPG. The Louisville Cardinals passing attack has averaged 238.5 yards per game, less than the Syracuse Orange give up through the air (263.25 YPG on average).

Defensively, the Syracuse Orange feature the league's No. 98-rated road run defense, allowing 219 yards per game. Louisville, meanwhile, ranks No. 113 in rushing offense at home.

Recent Outings Betting Recap

In their last game, Syracuse's aerial attack generated 348 yards but it was the Seminoles coming away with a 45-21 victory over Syracuse at Doak Campbell Stadium.

Last time out for the the Demon Deacons, they were scorched by Jamari Staples for 133 receiving yards against the Cardinals in a 20-19 loss at BB&T Field.

Betting Trends
  • Syracuse is 0-5 SU in its last 5 games
  • The total has gone OVER in 7 of Syracuse's last 8 games
  • Syracuse is 1-4 ATS in its last 5 games on the road
  • Syracuse is 0-5 SU in its last 5 games on the road
  • Louisville is 4-1 SU in its last 5 games
  • The total has gone UNDER in 5 of Louisville's last 6 games
  • Louisville is 2-6 ATS in its last 8 games at home
  • Louisville is 20-5 SU in its last 25 games at home

Next Betting Matchups

Syracuse home to Clemson, Saturday, November 14th
Louisville home to Virginia, Saturday, November 14th