The Buffalo Bills could have some more road trouble this Sunday when they visit the San Francisco 49ers at Candlestick Park. Buffalo is just 1-8 SU and 2-6-1 ATS over its last nine road games.

San Francisco is 16-4 SU and 14-6 ATS over its last 20 games and is 11-2 SU and 11-1-1 ATS in its last 13 games at home.



View Buffalo vs San Francisco Odds and Stats.

Betting Line:
The point spread was settled in at 8 favoring the host 49ers earlier in the week, according to Sportsbook. The over under line was hovering around 43.5, with movement expected during the week at Sportsbook.

Power Rankings / Prediction:
The Power Rankings at OddsShark have the No. 21-rated Bills taking on the No. 2-rated 49ers in this contest. Handicapping models indicate a 36-22 win for the 49ers on Sunday.



How They Match Up:
Offensively, the game matches up San Francisco's No. 12-ranked offense (26 PPG) against a Bills defense that ranks No. 30 at 32.8 PPG. The 49ers passing attack has averaged 179.2 yards per game, less than the Bills give up through the air (269.5 YPG on average).

Defensively, the Bills feature the league's No. 8-rated road run defense, allowing 75.5 yards per game. San Francisco, meanwhile, ranks No. 6 in rushing offense at home.

Last time out for Buffalo, they were a 52-28 loser as they battled the Patriots at home. The Bills failed to cover in the match as a 3.5-point underdog, while 80 combined points moved the game OVER for totals bettors. Buffalo comes off a game where it received a 4-TD performance from Ryan Fitzpatrick in a losing cause against the Patriots, a 52-28 final.

San Francisco was a 34-0 Sportsbook in its last match on the road against the Jets. They covered the 3.5-point spread as favorites, while the total score of 34 sent UNDER bettors to the payout window.


Buffalo Bills Trends:
When playing in October are 4-6
When playing on grass are 4-6
After being outgained are 4-6
When playing outside the division are 5-5

San Francisco 49ers Trends:
When playing in October are 6-4
When playing on grass are 8-2
After outgaining opponent are 7-3
When playing outside the division are 7-3

A few Bills at 49ers trends to consider:
The total has gone OVER in 6 of Buffalo's last 7 games
The total has gone OVER in 8 of Buffalo's last 11 games on the road
Buffalo is 4-9 ATS in its last 13 games
Buffalo is 3-10 SU in its last 13 games
San Francisco is 8-1 SU in its last 9 games at home
San Francisco is 16-4 SU in its last 20 games
The total has gone UNDER in 4 of San Francisco's last 6 games at home
San Francisco is 2-4 ATS in its last 6 games when playing Buffalo


Next up:
Buffalo at Arizona, Sunday, October 14
San Francisco home to NY Giants, Sunday, October 14