The Buffalo Bills (7-3 SU, 5-4-1 ATS) will travel to Detroit for the second time in less than a week as they visit the streaking Detroit Lions (4-6, 6-4) for Thursday’s early Thanksgiving game as large road favorites at sportsbooks monitored by Odds Shark.

The Bills were forced to play in the Motor City last Sunday due to a massive snowstorm in Buffalo – they knocked off the Cleveland Browns 31-23 as 7.5-point favorites – while the Lions are riding a three-game winning streak for the first time since 2017 after upsetting the New York Giants.

Bet On Bills vs Lions Here

Bills vs Lions Betting Preview

Bills vs Lions Opening Odds

Detroit has gotten a little respect from bettors following the team’s surprising 31-18 victory against the New York Giants as a 3-point road underdog last Sunday, moving down to a 9-point home dog in early wagering for this one. The total has also gotten some action, rising up to 54, with both teams topping the 30-point mark in their last two games.

Get the best Bills vs Lions odds and lines available from our recommended sportsbooks for your favorite picks of the night.

  • Best Spread
    -108
    -110
    BUF-9.5
    +9.5DET
  • Best Moneyline
    -435
    +355
    BUF
    DET
  • Best Total
    -110
    -110
    Over54.5
    55Under

Buffalo’s Travel Could Become Factor With Quick Turnaround

The Bills may not have been impacted too much on the field last week, but going home in between games rather than staying in Detroit could catch up to them in this spot. Their staff did not want to disrupt their weekly routine in preparation for games, although the short window between playing on Sunday and again on Thursday away from home in the same location is far from ideal.

That said, from a fantasy perspective, Buffalo still avoided a third consecutive loss vs Cleveland despite the lowest output of the season from quarterback Josh Allen. Allen completed 18 of 27 passes for a season-low 197 yards with one touchdown and added three carries for a season-low seven rushing yards.

Detroit Rocking and Rolling into Annual Thanksgiving Day Matchup

The Lions winning and the Los Angeles Rams losing seems to be the perfect combination for fans of them based on the trade of their former quarterback Matthew Stafford. Detroit receives another first-round pick from Los Angeles in 2023, and that selection is looking better and better the more the defending Super Bowl champions continue to lose.

So stacking up more wins does not really hurt the Lions’ draft positioning even though their second first-round pick would not be as good. The Rams currently have a worse record and figure to sustain even more losses due in part to Stafford’s injury status based on the concussion protocol. Regardless, Detroit’s confidence is now off the charts, and bettors do not have to worry about a potential tanking scenario with this team.   

Bills: Keys To Victory

Buffalo’s ability to cover the spread in this spot is tied directly to Allen’s performance. The Bills will have a difficult time winning by double digits if Allen does not play at an MVP level here. In fact, they suffered through a two-game skid just prior to their latest victory because Allen threw four interceptions. If he rebounds and plays better, Buffalo covers.

Lions: Keys To Victory

Detroit’s defense has been shockingly good in recent wins over New York and the Green Bay Packers, and that unit can be the difference-maker again in deciding whether the team wins or loses. The Lions certainly have the potential to stay within single digits if they can force Allen into turnovers and keep up on the scoreboard. They did just that against the Giants, jumping out to a 17-6 halftime lead and picking off quarterback Daniel Jones twice.

NFL Computer Pick: Lions +9 

Check out more of our signature NFL computer picks, plus our favorite sportsbooks that serve football customers. 

Join A Top-Tier NFL Betting Site Now

Shark Bites
  • Detroit is 3-0 SU and ATS in its last 3 games.
  • Detroit is 6-0 ATS in its last 6 November games.
  • Buffalo is 5-1 SU in the last 6 meetings.
Flag Our Top Sportsbooks
*Terms and Conditions apply to all bonus offers on this website. Please visit operator for details.
Top Pick
125% BONUS Up To $2500
Top Pick
50% BONUS Up To $1000
Top Pick
50% BONUS Up To $1000
Top Pick
50% BONUS Up To $1000
Top Pick
100% BONUS Up To $1000