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Buffalo Looks to Stay Hot vs San Francisco

The Buffalo Bills are 4-1 SU over their last five games and 3-0 ATS over their last three. The Bills will try to build on a strong performance against the Los Angeles Chargers with another win Monday night against the San Francisco 49ers in Arizona.


Buffalo Bills vs San Francisco 49ers
  • Date/Time: December 7, 5:15 p.m. ET
  • Stadium: State Farm Stadium
  • TV Coverage: ESPN
  • Opening Odds: Bills -2.5 | O/U 48 (Line History)
  • Bills vs 49ers Matchup Report

Opening Odds Analysis

The opening lines for this game have remained steady with the Bills going off as 2.5-point road favorites and the total set at 48 points. This will be Buffalo’s ninth game as a betting favorite; the Bills have gone 7-1 SU and 4-4 ATS in their past eight games as one. The OVER is 4-2 in the last six games between the Bills and 49ers.

Buffalo News & Notes

The Bills had their best defensive performance of the year last Sunday in their 27-17 win against the Chargers. In a game in which their offense was uncharacteristically out of sync, the team’s defense stepped up to hold the high-powered Chargers offense to just 17 points, also forcing a key fourth-quarter interception to secure the win.

Buffalo is now 4-1 SU over its last five games, and the only loss over that stretch was via a last-second Hail Mary against the Arizona Cardinals.

With an 8-3 SU and 6-5 ATS record, Buffalo enters December in first place in the AFC East. The Bills haven’t won their division since 1995, which was also the last year that Buffalo secured a postseason win. Important games against the Pittsburgh Steelers and Miami Dolphins loom large this month, but first the Bills have to focus on Monday night.

San Francisco News & Notes

Despite being decimated by injuries, the San Francisco defense managed to hound Jared Goff on Sunday and lead the 49ers to a 23-20 upset win over the Rams as 5-point underdogs in Los Angeles.

The defense forced four turnovers, including a 27-yard interception return for a touchdown, and only gave up 13 points as one of the Rams’ touchdowns came from a fumble return against the offense.

Wide receiver Deebo Samuel returned from injury and made an immediate impact, catching 11 passes for 133 yards. Samuel has 22 catches for 264 yards in his last three starts, and the 49ers are 3-0 SU and ATS in those three games.

San Francisco is technically still in the playoff hunt in the NFC with a 5-6 SU and ATS record. The 49ers will play the remainder of their home games in Arizona after their home county of Santa Clara banned contact sports due to COVID-19 concerns.

Betting Pick: Buffalo -2.5

It’s hard to imagine Josh Allen producing two dud games in a row, even against a capable San Francisco defense. The 49ers will continue to play tough, but they aren’t healthy enough to hang with this well-rounded Bills team.


Shark Bites
  • Buffalo is 5-0 ATS in its last 5 games vs the NFC.
  • San Francisco is 8-4 ATS in its last 12 games as an underdog.
  • The OVER is 8-3 in Buffalo’s last 11 games.