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49ers Search for Rare Home Victory in Week 1 Matchup with Carolina

The San Francisco 49ers will be aiming for their first SU win at home since Week 1 of 2016 when they host the Carolina Panthers in a season-opening matchup at Levi’s Stadium. The 49ers have covered just once during their current 0-7 SU run on home turf, but host a Panthers squad that tallied just two SU road wins last season.

Shark Bites
  • The total has gone OVER in 13 of the Panthers’ last 17 games against the 49ers.
  • The 49ers are 2-9 ATS in their last 11 games when hosting an East Coast team.
  • The total has gone UNDER in eight of the 49ers’ last 11 games as home underdogs.

The Panthers struggled to generate offense on the road last season, averaging just 16 points per game over their final five dates away from Bank of America Stadium. Carolina also surrendered a whopping 37.5 points per game over its past two visits to the West Coast, falling to defeat against Oakland and Seattle in the second half of the 2016 campaign.

Following a brutal 2-14 SU campaign in 2016, the 49ers have nowhere to go but up. San Francisco has lost by an average margin of 10.7 points during its current slide at home, but closed that gap in the final two home dates, including a narrow 25-23 loss to Seattle in Week 17.

However, Carolina has emerged as a reliable bet in recent meetings with the 49ers, going 13-2 ATS over their past 15 matchups.

Opening Odds & Computer Pick

Bettors who were going with the San Francisco 49ers in this one found them listed as 4-point underdogs on the betting line at Bovada. Fans betting on totals have seen that number set earlier in the week at 48.5 for Sunday.

OddsShark NFL prediction models pointed to a 24-18 result in favor of the 49ers on Sunday. View the computer score prediction and who will win the pick on the moneyline for all upcoming NFL matchups here.

Carolina Panthers vs San Francisco 49ers Matchup

Team Betting Records & Power Rankings

The Carolina Panthers will look to cover ATS vs their hosts on Sunday, as they were 6-8-2 ATS versus the spread last season, while the San Francisco 49ers were 4-11-1 ATS. Carolina was 8-8 against the OVER/UNDER total, while San Francisco was 10-6 versus the number. Stay Informed: follow us on Twitter for odds specials, betting line moves and San Francisco vs Carolina injuries news.

The 49ers-Panthers odds would favor the Panthers if the betting lines were set according to power ranks. San Francisco is rated No. 30 in our latest OddsShark poll, while the Panthers sit at No. 27.

Statistical Matchup

Offensively, the game matches up the San Francisco 49ers No. 26-ranked offense last season (19.31 PPG) against a Carolina Panthers defense that ranked No. 26 at 25.12 PPG. The 49ers passing attack averaged 181.94 yards per game, less than the Panthers gave up through the air (268.19 YPG on average).

Defensively, the Carolina Panthers featured the league's No. 9-rated road run defense, allowing 99.5 yards per game. The San Francisco 49ers, meanwhile, ranked No. 4 in rushing offense at home.

Recent Outings Betting Recap

In their last game, the Panthers were Week 17 losers coming out on the wrong end of 17-16 score against Tampa Bay.

Shaun Draughn scored twice in San Francisco's most recent game, but it still resulted in a loss, 25-23 versus Seattle at Levi's Stadium.

Betting Trends
  • Carolina is 4-2 ATS in its last 6 games
  • Carolina is 2-4 SU in its last 6 games
  • The total has gone UNDER in 6 of Carolina's last 9 games
  • Carolina is 3-8-1 ATS in its last 12 games on the road
  • San Francisco is 3-11-1 ATS in its last 15 games
  • San Francisco is 1-14 SU in its last 15 games
  • The total has gone OVER in 4 of San Francisco's last 6 games
  • San Francisco is 1-6 ATS in its last 7 games at home

Next Betting Matchups

Carolina home to Buffalo, Sunday, September 17
San Francisco at Seattle, Sunday, September 17