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Colts vs Broncos: Sunday Night Football

Peyton Manning will take on his old team once again on Sunday night as the Denver Broncos play host to an Indianapolis Colts team that has posted an 0-6 ATS mark in their last six season openers.

And at least one sportsbook is cheering for the Colts to continue their domination.

"We are sitting with about 75% of the money on Denver right now," said Kevin Bradley, sportsbook manager at Bovada.lv. It figures to be the most heavily wagered game of the weekend with a pair of sketchy Monday Nighters to follow.

The Colts are also 4-19 SU in their last 23 games as underdogs on the road, while the Broncos are 16-2 SU in their last 18 games as home favorites.

Denver is also 5-1 ATS in their last six season-opening contests at home as they try to start shaking off the stink from last year's ugly Super Bowl loss to the champion Seattle Seahawks.

The Colts are 6-0 SU and ATS past six games vs Broncos, however, making this large point spread a bit tricky. Of note, the OVER is 7-1 past eight meetings.

Indianapolis Colts vs Denver Broncos Opening Odds and Betting Line

Betting fans looking to back the visiting Indianapolis Colts in this one found them as 6-point underdogs earlier in the week at GTbets.eu, while the total was settling in the neighborhood of 55 at shops such as Bovada.

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Computer Prediction: Indianapolis Colts vs Denver Broncos Pick

Odds Shark computer prediction handicapping models run on this game pick a 34-27 victory for the Broncos. View the computer score prediction and who will win the pick on the moneyline for all upcoming NFL matchups here.

Indianapolis Colts vs Denver Broncos Odds and Stats.

Team Betting Records & Power Rankings

The Denver Broncos sit at 15-4 (11-8 ATS) on the season; in comparison, the Indianapolis Colts are currently 12-6 (11-7 ATS). Looking to bet on the totals? Denver is 12-7 OU, and Indianapolis is 10-8 OU. Stay Informed: follow us on Twitter for odds specials, betting line moves and Denver vs Indianapolis injuries news.

According to the Power Rankings here at Odds Shark it's the No. 3-rated Denver Broncos and the No. 15-rated Indianapolis Colts in this matchup.

How Indianapolis Colts vs Denver Broncos Stats Matchup

The game also pits Denver's No. 1-ranked offense, averaging 34.95 PPG, against a Colts defense that ranks No. 15 this week at 23.5 PPG. The Broncos aerial game is averaging 334.37 yards per game, more than the Colts secondary allows through the air, 236.61 YPG per game.

Defensively, the Indianapolis Colts feature the league's No. 27-rated road run defense, allowing 136.78 yards per game. The Denver Broncos, meanwhile, ranks No. 23 in rushing offense at home.

Recent Outings Betting Recap

Last time out for Indianapolis, they were a 43-22 loser as they battled the Patriots on the road. The Colts failed to cover in the match as a 7.5-point underdog, while 65 combined points moved the game OVER for totals bettors. In Indianapolis's last outing, Andrew Luck threw for 331 yards in a losing cause against the Patriots, 43-22 at Gillette Stadium.

Last time out for Denver, they were a 43-8 loser as they battled the Seahawks at home. The Broncos failed to cover in the match as a 2-point favorite, while 51 combined points moved the game OVER for totals bettors. Denver lost its last outing 43-8 against Seattle on Sunday, getting a 118-yard receiving performance from Demaryius Thomas in a losing cause at MetLife Stadium.

Indianapolis Colts vs Denver Broncos Betting Odds Trends

Indianapolis is 4-1 ATS in its last 5 games
Indianapolis is 4-1 SU in its last 5 games
The total has gone OVER in 8 of Indianapolis's last 12 games
The total has gone OVER in 5 of Indianapolis's last 6 games on the road
Denver is 8-4 ATS in its last 12 games
Denver is 4-1 SU in its last 5 games
The total has gone OVER in 15 of Denver's last 23 games
The total has gone UNDER in 5 of Denver's last 6 games

Next Betting Matchups

Indianapolis home to Philadelphia, Monday, September 15th
Denver home to Kansas City, Sunday, September 14th