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Monday Night Football: Week 6 Preview

The San Francisco 49ers have managed to pay out on the NFL betting lines in eight of their last nine games on Monday Night Football as they prepare to take on the Rams in St. Louis on Monday night.

And the Niners are pegged as 3-point road favorites at the online sportsbooks for the contest, as they look to improve on their 3-2 SU and 2-3 ATS marks on the season. The Rams, home underdogs for the game, sit at just 1-3 both SU and ATS on the season. The two teams are also a combined 3-6 on the OVER/UNDER heading into Monday night's matchup.

[ Check out the latest MNF odds at sportsbooks monitored by OddsShark.com ]

The Niners are 7-1-1 ATS in their last nine games as road favorites, and they've won two games in a row SU heading into Week 6. San Francisco beat Dallas in their opener, then lost to Chicago and Arizona before bouncing back with victories against Philadelphia and Kansas City. The Niners covered a 4.5-point home spread in a 22-17 win over the Chiefs last week.

The Rams' lone win on the season came back on September 14 against Tampa Bay, a 19-17 road victory as a 4.5-point underdog on the NFL betting lines. St. Louis lost 34-28 at Philadelphia last time out as a 4-point road underdog in their second straight OVER result.

San Francisco went 2-0 both SU and ATS against St. Louis last season, but overall they're just 1-3 ATS in the last four games between the two teams at the Edward Jones Dome. The OVER has gone 7-2 the last nine times that St. Louis has played on Monday Night Football.

Matchup Report: San Francisco @ St. Louis (Edward Jones Dome)

Betting Trends - San Francisco at St. Louis
49ers 8-1 ATS last nine Monday Night Football games
49ers 7-1-1 ATS last 9 games as road favorites
49ers 1-3 ATS last 4 meetings at St. Louis
49ers 3-9 ATS last 12 road games vs. NFC West
Rams 5-2 ATS last 7 home games vs. NFC West
Rams 1-4 ATS last 5 Monday Night Football games
OVER 7-2 in St. Louis' last 9 Monday Night Football games
OVER 3-1 in last 4 meetings at St. Louis
UNDER 4-0 in San Francisco’s last 4 games as road favorite

San Francisco Injuries
Tramaine Brock CB Out Week 6 (toe)
Anthony Davis T Questionable Week 6 (knee, ankle)
Vernon Davis TE Questionable Week 6 (back)
Marcus Martin C Questionable Week 6 (knee)
Nick Moody LB Questionable Week 6 (hamstring)
Chris Cook CB Probable Week 6 (quadricep)
Tony Jerod-Eddie DE Probable Week 6 (shoulder)
Andy Lee P Probable Week 6 (right ankle)
Ray McDonald DE Probable Week 6 (knee)
Justin Smith DE Probable Week 6 (not injury related)
Ian Williams DT Probable Week 6 (ankle)

St. Louis Injuries
Trumaine Johnson CB Out Week 6 (knee)
Brandon McGee CB Out Week 6 (foot)
Alex Carrington DT Questionable Week 6 (knee)
Jo-Lonn Dunbar LB Questionable Week 6 (groin)
Barrett Jones C Questionable Week 6 (back)
Chase Reynolds RB Questionable Week 6 (hip)
Kenny Britt WR Probable Week 6 (knee)
Eugene Sims DE Probable Week 6 (groin)
Zac Stacy RB Probable Week 6 (calf)