San Francisco blew a big lead against New England but came through late in the fourth quarter to earn a 41-34 win as a 3.5-point road underdog at the sportsbooks. That has the Niners at 10-3-1 SU and 9-5 ATS on the season.
The Seahawks, meanwhile, didn't have any trouble beating the Bills at the Rogers Centre in Toronto on Sunday, earning a 50-17 win as a 4.5-point favorite to sit at 9-5 SU and 10-4 ATS on the season.
San Francisco beat Seattle 13-6 as a 7.5-point home favorite back on October 18, and they'll clinch the NFC West title if they can beat the Seahawks on Sunday Night Football in a matchup that opened as a pick'em on the NFL betting lines at Sportsbook.
There were also three double-digit spreads on the Sportsbook NFL betting lines for Week 16, with New England a 15.5-point road favorite against Jacksonville, Green Bay a 13-point home favorite against Tennessee, and Denver a 14-point home favorite against Cleveland.
The Broncos ride a nine-game winning streak into their game against the Browns, which has them at 11-3 SU and 9-5 ATS on the season. Denver is also 5-0 SU and 4-1 ATS in its last five games against Cleveland dating back to 2000; the Browns are only 5-9 SU but sit at 8-5-1 ATS heading into their game this weekend.
Week 16 Sportsbook NFL Betting Lines (from Sportsbook)
Sat - Atlanta at Detroit (+3.5) (8:30pm ET)
Sun - New Orleans at Dallas (-3) (1:00pm ET)
Sun - Tennessee at Green Bay (-13) (1:00pm ET)
Sun - Indianapolis at Kansas City (+6) (1:00pm ET)
Sun - Buffalo at Miami (-4) (1:00pm ET)
Sun - San Diego at NY Jets (-3) (1:00pm ET)
Sun - Washington at Philadelphia (+4) (1:00pm ET)
Sun - Cincinnati at Pittsburgh (-4.5) (1:00pm ET)
Sun - St. Louis at Tampa Bay (-3) (1:00pm ET)
Sun - Oakland at Carolina (-9.5) (1:00pm ET)
Sun - New England at Jacksonville (+15.5) (1:00pm ET)
Sun - Minnesota at Houston (-9.5) (1:00pm ET)
Sun - Cleveland at Denver (-14) (4:05pm ET)
Sun - Chicago at Arizona (+5) (4:25pm ET)
Sun - NY Giants at Baltimore (pick) (4:25pm ET)
Sun - San Francisco at Seattle (pick) (8:20pm ET)
Week 16 NFL Betting Trends and Notes
Atlanta at Detroit - Matchup Report
The total has gone UNDER in 5 of Atlanta's last 5 games when playing on the road against Detroit
The total has gone UNDER in 5 of Detroit's last 5 games when playing at home against Atlanta
New England at Jacksonville - Matchup Report
New England is 5-0 SU in its last 5 games when playing Jacksonville
The total has gone UNDER in 6 of Jacksonville's last 8 games at home
St. Louis at Tampa Bay - Matchup Report
The total has gone UNDER in 4 of St. Louis's last 5 games when playing on the road against Tampa Bay
Tampa Bay is 5-0 SU in its last 5 games when playing at home against St. Louis
Oakland at Carolina - Matchup Report
The total has gone UNDER in 5 of Oakland's last 5 games
The total has gone OVER in 4 of Carolina's last 6 games
Indianapolis at Kansas City - Matchup Report
Indianapolis is 10-2 SU in its last 12 games when playing Kansas City
The total has gone UNDER in 5 of Kansas City's last 6 games
San Diego at NY Jets - Matchup Report
The total has gone OVER in 5 of San Diego's last 6 games on the road
The total has gone UNDER in 5 of the NY Jets last 7 games
New Orleans at Dallas - Matchup Report
New Orleans is 6-1 SU in its last 7 games when playing Dallas
Dallas is 5-1 SU in its last 6 games
Buffalo at Miami - Matchup Report
The total has gone UNDER in 5 of Buffalo's last 6 games when playing on the road against Miami
The total has gone UNDER in 5 of Miami's last 6 games when playing at home against Buffalo
Tennessee at Green Bay - Matchup Report
The total has gone UNDER in 4 of Tennessee's last 5 games
The total has gone UNDER in 5 of Green Bay's last 5 games
Washington at Philadelphia - Matchup Report
Washington is 5-0 SU in its last 5 games
The total has gone OVER in 5 of Philadelphia's last 5 games at home
Minnesota at Houston - Matchup Report
Minnesota is 3-5-1 ATS in its last 9 games
Houston is 7-1 SU in its last 8 games
Cincinnati at Pittsburgh - Matchup Report
Cincinnati is 5-1 SU in its last 6 games
Pittsburgh is 5-0 SU in its last 5 games when playing Cincinnati
Cleveland at Denver - Matchup Report
The total has gone UNDER in 4 of Cleveland's last 5 games on the road
Denver is 5-0 SU in its last 5 games
Chicago at Arizona - Matchup Report
The total has gone OVER in 4 of Chicago's last 5 games on the road
The total has gone OVER in 4 of Arizona's last 5 games when playing at home against Chicago
NY Giants at Baltimore - Matchup Report
The total has gone UNDER in 8 of the NY Giants last 9 games on the road
Baltimore is 16-2 SU in its last 18 games at home
San Francisco at Seattle - Matchup Report
The total has gone OVER in 5 of San Francisco's last 6 games
Seattle is 5-0 SU in its last 5 games at home
