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NFL Opening Betting Lines: Week 6 Odds

Home underdogs make up a large chunk of the Week 6 opening NFL betting lines, with the Houston Texans one of those teams getting points in their own stadium as they host the Indianapolis Colts on Thursday Night Football this week.

The Texans opened as 2-point home underdogs against the Colts on the NFL odds for this week, with those teams tied atop the AFC South standings with identical marks of 3-2 SU and 4-1 ATS. The Colts are 3-0 both SU and ATS in their last three against the Texans, according to the betting trends for Week 6.

[ See the updated NFL Week 6 odds right now on the OddsShark NFL Odds page ]

Six other games opened with home underdogs for this week, including Baltimore at Tampa Bay +3.5, Denver at the Jets +6, Detroit at Minnesota +3, Green Bay at Miami +3, and San Diego at Oakland +7. As well, St. Louis opened as a 4-point home underdog against San Francisco for Monday Night Football; the Niners are 7-1-1 ATS in their last nine games as road favorites.

As well, the New England at Buffalo game opened as a pick'em, although the Patriots' convincing win on Sunday Night Football over the Bengals pushed Tom Brady and company to 3-point road favorites by Monday night. The Pats are 20-1 SU in their last 21 games against the Bills.

Matchup Reports: Indy vs. Houston | San Francisco vs. St. Louis | New England vs. Buffalo

Elsewhere around the Week 6 opening odds at the sportsbooks it was Tennessee favored by 6 points at home over winless Jacksonville, Cincinnati favored by 7 points at home over Carolina, and Cleveland favored by 2 points at home over rival Pittsburgh. The Eagles opened as 3-point home favorites over the Giants for Sunday Night Football; Philadelphia is 9-3 ATS in its last 12 games against New York.

Week 6 NFL Opening Betting Lines:

Indianapolis at Houston (+2), 8:25pm ET

Jacksonville at Tennessee (-6), 1:00pm ET
Baltimore at Tampa Bay (+3.5), 1:00pm ET
Denver at NY Jets (+6), 1:00pm ET
Detroit at Minnesota (+3), 1:00pm ET
New England at Buffalo (pick'em), 1:00pm ET
Carolina at Cincinnati (-7), 1:00pm ET
Pittsburgh at Cleveland (-2), 1:00pm ET
Green Bay at Miami (+3), 1:00pm ET
San Diego at Oakland (+7), 4:05pm ET
Chicago at Atlanta (-3), 4:25pm ET
Dallas at Seattle (-8.5), 4:25pm ET
Washington at Arizona (-4), 4:25pm ET
NY Giants at Philadelphia (-3), 8:30pm ET

San Francisco at St. Louis (+4), 8:30pm ET