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NFL Week 13 Opening Odds Analysis

And then there was one - and it's not the New England Patriots. Even Nostradamus would have been hard-pressed to accurately predict that the Carolina Panthers would be the lone unbeaten NFL team after 12 weeks.

Next up for the 11-0 Panthers is a road date against NFC South Division rival New Orleans on Sunday. The Panthers opened as seven-point favorites. The last time Carolina was a road favorite against the Saints was 2008 when John Fox was the Panthers coach.

During the past six seasons, the Panthers were an average of 7.8-point road underdogs to the Saints. Now they're road chalk against New Orleans, who gives up the most points in the league at 30.8 per game.

Carolina steamrolled the Saints, 41-10, as nine-point road 'dogs last season. The Panthers slipped past the Saints, 27-22, as 10-point home favorites when the Saints started backup Luke McCown for injured Drew Brees back in Week 3 of this season. Brees is back, but has just five touchdown throws in his last three games following a seven-touchdown throwing performance versus the Giants.

Packers Small Favorites in Lions Rematch

There are five other games on the Week 13 menu that are rematches. Green Bay and Tennessee are in quick revenge spots.

The Packers lost to Detroit just two games ago, 18-16, as whopping 10.5-point favorites. It was the first time the Packers lost to the Lions in Wisconsin since 1991. The spread is much shorter this time around. Green Bay is minus three for Thursday's matchup at Ford Field.

Jacksonville and Tennessee met just two weeks ago, too, and the Jaguars came from behind to win, 19-13, as three-point home favorites. Now the Titans are minus 2.5 despite having lost their last 11 home contests. The Jaguars lost respect from the oddsmakers and goodwill from bettors losing 31-25 to San Diego as a five-point home favorite this past Sunday.

Cincinnati opened a touchdown road favorite against Cleveland. The Browns hung in for a half with Johnny Manziel before losing, 31-10, to the Bengals as 13-point underdogs in Week 9.

Arizona is in a revenge spot laying 5.5 at St. Louis. The Rams upset the Cardinals, 24-22, as seven-point road 'dogs in Week 4.