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Drew Brees and the New Orleans Saints remain the biggest favorite on the board for Week 5 of the NFL season heading into their home game at the Superdome against the Tampa Bay Buccaneers on Sunday afternoon.

The Saints are big 11.5-point favorites against the Bucs, who are just 2-8 ATS in their last 10 road games vs. NFC South teams. And New Orleans has been a good friend to bettors at home recently, going 20-3-1 ATS in their last 24 home games as favorites.

Matchup Reports: Tampa Bay vs. New Orleans | Pittsburgh vs. Jacksonville | Buffalo vs. Detroit

Can the Jacksonville Jaguars finally get a win this week? The Jaguars are touchdown-underdogs at home against Ben Roethlisberger and the Pittsburgh Steelers on Sunday afternoon, but Jacksonville is 6-2 ATS in its last eight games against Pittsburgh. As for the Steelers, they're just 2-8 ATS in their last 10 games as road favorites.

On the injury front, Detroit Lions wide receiver Calvin Johnson is listed as questionable with his ankle injury for their game at home against the Buffalo Bills on Sunday afternoon, leaving him as a game-time decision. Detroit, a 7-5-point home favorite, is 3-6 ATS in its last nine games against AFC East teams.

For Sunday night the New England Patriots and the Cincinnati Bengals are a pick'em on the NFL odds, with Tom Brady and company losing support over the course of the week. Should that line shift further toward the Bengals bettors will note that New England is 8-1 ATS in its last nine games as a home underdog.

Week 5 NFL Betting Content at OddsShark

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