Odds Shark Top Sportsbooks
*Terms and Conditions apply to all bonus offers on this website. Visit operator for details.

Eagles, 49ers Match Up for Defensive Showdown

Eagles vs 49ers Betting Odds Carson Wentz

Sunday Night Football sees two quality defenses take the field as the underachieving Philadelphia Eagles visit the injury-depleted San Francisco 49ers. The Eagles (0-2-1 SU, 0-3 ATS) are coming off a rare tie and may be the most disappointing team in the league from an expectation standpoint. The 49ers (2-1 SU, 2-1 ATS) return home after dusting both New York teams in the Big Apple despite their injuries.

Philadelphia Eagles vs San Francisco 49ers
  • Date/Time: October 4, 8:30 p.m. ET
  • Stadium: Levi’s Stadium
  • TV Coverage: NBC
  • Opening Odds: 49ers -6 | O/U 47.5 (Line History)
  • Eagles vs 49ers Matchup Report

Opening Odds Analysis

The line opened with the 49ers as favorites at -6 and that number has moved slightly to -6.5 at most books while staying at -6 at a few others. The total opened at 47.5 and has moved down to 45 across the board.

Philadelphia News & Notes

Carson Wentz’s struggles this season have some of the Philly faithful calling for a change at quarterback. Wentz, who has thrown just seven interceptions in each of the last three seasons, has six through three games and just three touchdowns. He is sporting a paltry 35.5 QBR on the year, good for 29th in the league.

It does not help that his arsenal of weapons is riddled with injuries. Receiver Alshon Jeffery has yet to play a game. Rookie first-round wideout Jalen Reagor is out indefinitely. And tight end Dallas Goedert and receiver DeSean Jackson both left Week 3’s game with injuries. Goedert has already been ruled out for Week 4.

The lone bright spot for Philly is a defense that has allowed the sixth-fewest yards per game. The Eagles’ ferocious defensive front presents a tough matchup for the 49ers.

San Francisco News & Notes

The 49ers won 36-9 on the road in Week 3 without their starting quarterback, top two running backs, star tight end, multiple starting defensive linemen and top cornerback. That game may say more about the New York Giants, but the Niners have proven to be a deep, quality team with a masterful coaching staff.

While the Eagles defense is a tough matchup for backup QB Nick Mullens, San Francisco has shown the ability to scheme its way to victory through creative play-calling. As one of the last men standing, look for first-round rookie speedster Brandon Aiyuk to get plenty of looks. Aiyuk was used in a variety of ways in Week 3, posting five receptions for 70 yards and three carries for 31 yards and a touchdown.

Betting Pick: 49ers -6.5

It feels like a matter of time before we see the Eagles play better on offense. However, it won’t be this week as the team is simply missing too many horses. A bare-bones receiving corps and a struggling quarterback isn’t the recipe for success on the road against one of the better teams in the league (despite the 49ers’ own injury situation).

Shark Bites
  • Philadelphia is 7-1 ATS in its last 8 games vs San Francisco.
  • The OVER is 5-0 in Philadelphia’s last 5 road games.
  • The 49ers are 15-5 SU in their last 20 games.