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Week 3 NFL Betting Odds with Pick - San Francisco 49ers vs Arizona Cardinals

The Cardinals will look to continue their strong start to the season against a 49ers team that is 8-2 ATS in their last 10 games in Arizona. The Cards have been almost unbeatable at home over their last eight games, going 7-1 SU and ATS.

Shark Bites
  • The 49ers are 0-4 ATS in their last four divisional games.
  • The Cardinals are 7-1 SU in their last eight games as September favorites.
  • Chris Johnson is likely to start at running back for the Cardinals.

After a promising start to the season, the 49ers allowed 43 points in Pittsburgh in Week 2. They're 0-4 ATS in their last four divisional games and the total has gone UNDER in seven of their last nine games.

The teams split their season series last season, with each team winning their home game.

Opening Odds & Computer Pick

Betting fans looking to back the visiting San Francisco 49ers in this one found them as 6-point underdogs earlier in the week, while the total was settling in the neighborhood of 44.5 at shops such as Bovada.

Odds Shark computer prediction handicapping models run on this game pick a 29-20 victory for the Cardinals. View the computer score prediction and who will win the pick on the moneyline for all upcoming NFL matchups here.

San Francisco 49ers vs Arizona Cardinals Matchup

Team Betting Records & Power Rankings

Supporters of the San Francisco 49ers have seen them go 1-1 and 1-1 ATS so far this season, while the Arizona Cardinals are at 2-0 and 2-0 ATS. In totals betting, the Cardinals are 2-0, while the 49ers are 1-1. Stay Informed: follow us on Twitter for odds specials, betting line moves and Arizona vs San Francisco injuries news.

The power rankings show a disparity between these teams, with the Arizona Cardinals rated this week at No. 20 and the San Francisco 49ers sitting at No. 25.

Statistical Matchup

The game also pits Arizona's No. 1-ranked offense, averaging 39.5 PPG, against a 49ers defense that ranks No. 17 this week at 23 PPG. The Cardinals aerial game is averaging 246 yards per game, less than the 49ers secondary allows through the air, 273 YPG per game.

In comparing defenses, the San Francisco 49ers own the league's No. 6-rated front 7 in terms of stopping the run, allowing 84 yards per game when on the road. Arizona, on the other hand, rates No. 11 this week in generating rushing yards at home.

Recent Outings Betting Recap

In San Francisco's last outing, Colin Kaepernick threw for 335 yards in a losing cause against the Steelers, 43-18 at Heinz Field.

Carson Palmer dusted the Bears secondary for 4 TDs last time out as the Cardinals defeated Chicago 48-23 at Soldier Field.

Betting Trends
  • San Francisco is 1-7 ATS in its last 8 games
  • San Francisco is 2-5 SU in its last 7 games
  • The total has gone UNDER in 7 of San Francisco's last 9 games
  • San Francisco is 2-4 ATS in its last 6 games on the road
  • Arizona is 11-4 ATS in its last 15 games
  • Arizona is 16-7 SU in its last 23 games
  • The total has gone OVER in 4 of Arizona's last 5 games
  • Arizona is 7-1 ATS in its last 8 games at home

Next Betting Matchups

San Francisco home to Green Bay, Sunday, October 4th
Arizona home to St. Louis, Sunday, October 4th