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Bills Gunning for Fourth Straight Win in Home Date with Fading Niners

The Buffalo Bills will be trying to win four straight games for the first time since the start of the 2008 NFL season when they host the freefalling San Francisco 49ers on Sunday afternoon in an NFL Week 6 matchup at New Era Field.

Shark Bites
  • The Bills are 6-0 SU and ATS in their last six games after losing the previous game in a matchup.
  • The total has gone OVER in eight of the 49ers' last 10 games on the road.
  • The 49ers are 1-10 SU and 2-9 ATS in their last 11 games as road underdogs.

The Bills followed up a pair of impressive upset wins over Arizona and New England with a 30-19 victory in Los Angeles last weekend, covering as 2.5-point road favorites after opening as 3-point underdogs. Buffalo is now 5-2, straight up and against the spread, over their past seven, holding opponents to 19 or fewer points in six of those contests.

San Francisco is coming off its fourth straight defeat, SU and ATS, falling by an average margin of 14.25 points during that slide. The 49ers have been particularly bad on the road, going winless SU and ATS in their past four, and 1-11 SU, 2-10 ATS, since Week 14 of the 2014 campaign.

The 49ers claimed victory in their past two clashes with Buffalo, including a narrow 10-3 win as 7-point underdogs in their last visit to Western New York eight years ago, and have covered in seven straight against AFC East opponents. However, they face a Bills squad that is an impressive 5-1 SU and ATS in its past six at home.

Opening Odds & Computer Pick

The Buffalo Bills were listed as -7-point favorites at Bovada and other online Sportsbooks, with the total listed at one point at 45.5.

Odds Shark computer prediction formulas pick a 25-17 win for the Bills on Sunday. View the computer score prediction and who will win the pick on the moneyline for all upcoming NFL matchups here.

San Francisco 49ers vs Buffalo Bills Matchup

Team Betting Records & Power Rankings

This season the Buffalo Bills are 3-2 overall and 3-2 ATS against the spread, while the 49ers are 1-4 and 1-4 ATS. As for the totals, Buffalo is 3-2 on the OU, and San Francisco is 3-2. Stay Informed: follow us on Twitter for odds specials, betting line moves and Buffalo vs San Francisco injuries news.

According to the Power Rankings here at Odds Shark it's the No. 9-rated Buffalo Bills and the No. 27-rated San Francisco 49ers in this matchup.

Statistical Matchup

Offensively, the game matches up the Buffalo Bills No. 15-ranked offense (23.4 PPG) against a San Francisco 49ers defense that ranks No. 26 at 28 PPG. The Bills passing attack has averaged 169.2 yards per game, less than the 49ers give up through the air (222.8 YPG on average).

In comparing defenses, the San Francisco 49ers own the league's No. 30-rated front 7 in terms of stopping the run, allowing 151.5 yards per game when on the road. Buffalo, on the other hand, rates No. 2 this week in generating rushing yards at home.

Recent Outings Betting Recap

Jeremy Kerley was good for 102 receiving yards in the 49ers's most recent action, but while it helped his stats, it didn't help his team to victory and they fell 33-21 to the 49ers.

LeSean McCoy tore up the turf for 150 rushing yards in the latest Bills game, a 30-19 win over the Rams at Los Angeles Memorial Coliseum.

Betting Trends
  • San Francisco is 1-4 ATS in its last 5 games
  • San Francisco is 1-4 SU in its last 5 games
  • San Francisco is 1-6 ATS in its last 7 games on the road
  • San Francisco is 1-11 SU in its last 12 games on the road
  • Buffalo is 5-2 ATS in its last 7 games
  • Buffalo is 5-2 SU in its last 7 games
  • Buffalo is 5-1 ATS in its last 6 games at home
  • Buffalo is 5-1 SU in its last 6 games at home

Next Betting Matchups

San Francisco home to Tampa Bay, Sunday, October 23rd
Buffalo at Miami, Sunday, October 23rd