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49ers Take Losing Streak into Week 5 matchup in Indianapolis

The San Francisco 49ers continue the search for their first SU win of the season on Sunday afternoon, when they visit the struggling Indianapolis Colts in an NFL Week 5 matchup at Lucas Oil Stadium. The Niners have tallied just one win in their past 12 road dates while the Colts look to rebound from a lopsided 46-18 loss in Seattle as 12.5-point underdogs last Sunday night.

Shark Bites
  • The 49ers are 3-1 ATS in their last four games on the road against the Colts.
  • The total has gone UNDER in six of the Colts’ last seven games in the early afternoon.
  • The Colts are 3-1 SU in their last four games when hosting a West Coast team.

San Francisco has struggled to generate offense during its current five-game SU slide, averaging just 12 points per game in a pair of road losses, but has been a pleasant surprise at the sportsbooks, covering in five of its past six. The 49ers have also been a reliable bet when pegged as an underdog by three or fewer points, going 6-2-1 ATS in their past nine while claiming outright wins on five occasions.

Conversely, the inconsistent Colts have allowed 46 points in each of their two road losses, but have allowed less than half that number while going 1-1 SU at home. With quarterback Andrew Luck out of the lineup, Indianapolis has also faced offensive challenges, averaging just 13.3 ppg in its three losses this season.

However, the Colts have dominated San Francisco in three straight wins, limiting the 49ers to just 8 ppg. These two teams combined to score fewer than 33 ppg in those contests, fueling a 3-0 run for the UNDER in totals betting.

Opening Odds & Computer Pick

Betting fans looking to back the visiting San Francisco 49ers in this one found them as 1.5-point underdogs earlier in the week, while the total was settling in the neighborhood of 43 at shops such as Bovada.

OddsShark computer NFL score prediction models picked a possible 26-16 win for the Colts on Sunday. That score may change during the week, if injury or weather factors alter the numbers, so check the NFL picks page before game time. View the computer score prediction and who will win the pick on the moneyline for all upcoming NFL matchups here.

San Francisco 49ers vs Indianapolis Colts Matchup

Team Betting Records & Power Rankings

Indianapolis brings a 1-3 record (2-2 ATS) to the Week 5 betting matchup against the 0-4 San Francisco 49ers, who are 3-1 against the spread. OVER/UNDER betting has seen Indianapolis go 3-1 so far and the 49ers go 1-3. Stay Informed: follow us on Twitter for odds specials, betting line moves and Indianapolis vs San Francisco injuries news.

The OddsShark Power Rankings have the Indianapolis Colts at No. 24 and the San Francisco 49ers at No. 29 heading into this contest.

Statistical Matchup

Offensively, the game matches up the Indianapolis Colts' No. 25-ranked offense (17.75 PPG) against a San Francisco 49ers defense that ranks No. 24 at 23.5 PPG. The Colts passing attack has averaged 180.5 yards per game, less than the 49ers give up through the air (240.25 YPG on average).

Defensively, the San Francisco 49ers feature the league's No. 10-rated road run defense, allowing 91 yards per game. The Indianapolis Colts, meanwhile, rank No. 21 in rushing offense at home.

Recent Outings Betting Recap

The 49ers suffered a Week 4 loss against Arizona in their last game, falling 18-15 at University of Phoenix Stadium.

Indianapolis was hammered in its last outing, as Seattle ran up a 46-18 score against them at CenturyLink Field.

Betting Trends
  • San Francisco is 5-1 ATS in its last 6 games
  • San Francisco is 6-12-1 ATS in its last 19 games
  • San Francisco is 0-5 SU in its last 5 games
  • San Francisco is 6-13-1 ATS in its last 20 games on the road
  • Indianapolis is 2-4 ATS in its last 6 games
  • Indianapolis is 2-4 SU in its last 6 games
  • The total has gone OVER in 4 of Indianapolis's last 6 games
  • The total has gone UNDER in 6 of Indianapolis's last 7 games at home

Next Betting Matchups

San Francisco at Washington, Sunday, October 15
Indianapolis at Tennessee, Monday, October 16