OddsShark Top Sportsbooks

*Terms and Conditions apply to all bonus offers on this website. Please visit operator for details.

Pittsburgh Steelers Hosting the San Francisco 49ers Week 2 Odds and Betting Pick

After coming up short in their season opener the Pittsburgh Steelers will get a second chance at a first win on Sunday afternoon as they play host to the San Francisco 49ers at Heinz Field as clear betting favorites on the NFL odds.

The Steelers lost 28-21 to the Patriots in the Thursday night opener in Week 1, playing that game without suspended running back Le'Veon Bell, who won't be eligible to play against the Niners this weekend either. In his absence DeAngelo Williams ran for 127 yards on 21 carries against New England.

Niners supporters could be looking at UNDER trends for this matchup on Sunday, as the UNDER is 3-0 in San Francisco's last three games on the road and 5-1 in the team's last six games away from home in the month of September.

Opening Odds & Computer Pick

The Pittsburgh Steelers were listed as -6.5-point favorites at Bovada and other online Sportsbooks, with the total listed at one point at 45.

Odds Shark computer prediction handicapping models run on this game pick a 26-23 victory for the Steelers. View the computer score prediction and who will win the pick on the moneyline for all upcoming NFL matchups here.

San Francisco 49ers vs Pittsburgh Steelers Matchup

Team Betting Records & Power Rankings

Pittsburgh bring a 0-1 record (0-0-1 ATS) to the Week 2 betting matchup against the 1-0 San Francisco 49ers, who are 1-0 ATS against the spread. Over under betting has seen Pittsburgh go 0-1 so far and the 49ers go 0-1. Stay Informed: follow us on Twitter for odds specials, betting line moves and Pittsburgh vs San Francisco injuries news.

According to the Power Rankings here at Odds Shark it's the No. 6-rated Pittsburgh Steelers and the No. 23-rated San Francisco 49ers in this matchup.

Recent Outings Betting Recap

Carlos Hyde went over the 100-yard mark (168) in his team's latest effort as San Francisco defeated Minnesota by a score of 20-3 on Monday.

Ben Roethlisberger led the way last time out for the Steelers, connecting for 351 passing yards, but failing to earn the victory in a 28-21 loss to the Steelers at Gillette Stadium.

Betting Trends
  • San Francisco is 1-6 ATS in its last 7 games
  • San Francisco is 2-4 SU in its last 6 games
  • The total has gone UNDER in 7 of San Francisco's last 8 games
  • San Francisco is 12-6 SU in its last 18 games on the road
  • Pittsburgh is 4-1-1 ATS in its last 6 games
  • Pittsburgh is 4-2 SU in its last 6 games
  • The total has gone UNDER in 4 of Pittsburgh's last 5 games
  • Pittsburgh is 5-2 ATS in its last 7 games at home

Next Betting Matchups

San Francisco at Arizona, Sunday, September 27th
Pittsburgh at St. Louis, Sunday, September 27th