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Power Ranking
San Francisco 17
Buffalo 5
Betting Odds Preview

San Francisco 49ers at Buffalo Bills

The Buffalo Bills will be trying to win four straight games for the first time since the start of the 2008 NFL season when they host the freefalling San Francisco 49ers on Sunday afternoon in an NFL Week 6 betting matchup at New Era Field.

Smart Chart
  • SF
  • 28.55
  • 18.75
  • 9.80
  • 257.95
  • 138.25
  • 221.05
  • 98.65
  • -0.6
  •  
  • Offense
  • Defense
  • Differential
  • Passing Yards
  • Rush Yards
  • Passing Yards Allowed
  • Rushing Yards Allowed
  • Turnover Differential
  • BUF
  • 26.63
  • 18.68
  • 7.95
  • 238.37
  • 135.42
  • 198.68
  • 112.21
  • -0.27
Head to Head Summary

No data available.

Team Record
San Francisco 49ers
All Last 3 vs Conf vs Div
Record1-40-31-41-2
Home1-20-21-21-1
Away0-20-10-20-1
ATS1-40-31-41-2
ATS Home1-20-21-21-1
ATS Away0-20-10-20-1
Offense22.2018.6713.4022.33
Defense28.0031.3314.0023.33
Diff-5.80-12.67-0.60-1.00
Team Record
Buffalo Bills
All Last 3 vs Conf vs Div
Record3-23-01-21-1
Home1-11-00-10-1
Away2-12-01-11-0
ATS3-23-01-21-1
ATS Home1-11-00-10-1
ATS Away2-12-01-11-0
Offense23.4026.3315.6723.50
Defense17.4012.3312.3318.50
Diff6.0014.003.335.00
Head to Head Detail
Search NFL DatabaseTeamsPoints ScoredRush YardsPass YardsTotal YardsTurnovers
Oct 7, 2012BUF3891152042
SF453113106211
Nov 30, 2008SF10621331951
BUF31561943501
Dec 26, 2004BUF412262154411
SF798911894
Dec 2, 2001BUF0291621915
SF352301794090
Oct 4, 1998SF21653123774
BUF261152373520
Dec 3, 1995BUF17841912755
SF271022213231
Sep 13, 1992BUF340000
SF310000
Dec 17, 1989BUF100000
SF210000
Dec 11, 1983SF230000
BUF100000
Dec 21, 1980BUF180000
SF130000
Betting Odds Trends
Betting Odds Trends
Injuries
San Francisco 49ers
  • Trent Williams T Is "?" Thursday vs LA Rams, Ankle
  • Tashaun Gipson Sr. S Is out indefinitely, Suspension
  • Javon Hargrave NT Is out for season, Triceps
  • Christian McCaffrey RB IR, Knee
  • George Odum S Is "?" Thursday vs LA Rams, Undisclosed
  • Nick Bosa DE Is "?" Thursday vs LA Rams, Hip
  • Mitch Wishnowsky P IR, Back
  • Kevin Givens DT IR; is out for season, Pectoral
  • Brandon Aiyuk WR IR; is out for season, ACL
  • Ben Bartch T Left last game, is "?" Thursday vs LA Rams, Ankle
  • Aaron Banks G Is "?" Thursday vs LA Rams, Concussion
  • Ambry Thomas CB IR, Undisclosed
  • Eli Mitchell RB IR, Hamstring
  • Curtis Robinson LB Is out for season, ACL
  • Jordan Mason RB IR, Ankle
  • Jake Moody K Is out indefinitely, Ankle
  • Darrell Luter Jr. CB IR, Pelvis
  • Tatum Bethune LB IR, Knee
  • Isaac Guerendo RB Is "?" Thursday vs LA Rams, Foot
Injuries
Buffalo Bills
  • Dawuane Smoot DE IR, Wrist
  • Quintin Morris TE Is "?" Sunday vs Detroit, Shoulder
  • Shane Buechele QB IR, Neck
  • Dalton Kincaid TE Is "?" Sunday vs Detroit, Knee
  • Keon Coleman WR Is "?" Sunday vs Detroit, Wrist
  • Travis Clayton T IR, Shoulder
Last 5 Games
San Francisco 49ers
Date OPP Score SU Line ATS Off. Rush Off. Pass Off. Total Def. Rush Def. Pass Def. Total TO
Oct 6, 2016ARI21-33L3.5/43L/O1511352861721162883
Oct 2, 2016DAL17-24L1.5/44L/U1061892951942344281
Sep 25, 2016SEA18-37L10/42L/O135119254127291418-1
Sep 18, 2016CAR27-46L12.5/44.5L/O65237302176353529-1
Sep 12, 2016LAR28-0W2.5/43.5W/U15017032065120185-1
Buffalo Bills
Date OPP Score SU Line ATS Off. Rush Off. Pass Off. Total Def. Rush Def. Pass Def. Total TO
Oct 9, 2016LAR30-19W-2.5/41.5W/O193112305102243345-3
Oct 2, 2016NE16-0W3.5/41W/U13424437890187277-1
Sep 25, 2016ARI33-18W4.5/48W/O20888296114234348-4
Sep 15, 2016NYJ31-37L-1/40.5L/O863073931233704930
Sep 11, 2016BAL7-13L3/44.5L/U659516083225308-1
Offensive Comparison

No data available.

Defensive Comparison
San Francisco 49ers
Buffalo Bills

Scoring Allowed

Points Allowed

18.75 18.68

Last 3 Games

31.33 12.33

Yards Per Point

13.88 14.04

Overall Yards Allowed

Total

319.7 310.89

Passing

221.05 198.68

Rushing

98.65 112.21

On Road vs. At Home Yards Allowed

Total

330.1 305

Passing

231.80 193.00

Rushing

98.30 112.00
Supergrid
Stat Rank Stat Rank
Away Team Overall Scoring vs Home Team Overall Defense28.55218.683
Away Team Road Passing vs Home Team Home Passing Defense234.508193.008
Away Team Road Rushing vs Home Team Home Rushing Defense141.702112.0018
Home Team Overall Scoring vs Away Team Overall Defense26.63618.754
Home Team Home Passing vs Away Team Road Passing Defense224.6416231.8021
Home Team Home Rushing vs Away Team Road Rushing Defense148.64698.308
Recent Form

No data available.

Power Stats
  • SF
  • 13.88
  • 17.05
  • -3.17
  •  
  • 12.8
  • 9.02
  • 3.78
  •  
  • 4.71
  • 4.33
  • 0.38
  • Yards Per Point
  • Offense
  • Defense
  • Differential
  • Yards Per Pass
  • Offense
  • Defense
  • Differential
  • Yards Per Rush
  • Offense
  • Defense
  • Differential
  • BUF
  • 14.04
  • 16.64
  • -2.61
  •  
  • 10.48
  • 9.39
  • 1.09
  •  
  • 4.4
  • 4.68
  • -0.28
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