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The San Francisco 49ers (12-7 SU, 11-8 ATS) are 6-0 SU and 5-1 ATS in their last six games against the Los Angeles Rams (14-5, 10-9). The 49ers will try to pull off an upset and succeed as a 49ers vs Rams prediction Sunday night in Los Angeles in the NFC championship game.

49ers vs Rams Betting Preview

49ers vs Rams Odds & Analysis

Opening Odds

The Rams opened as 3.5-point favorites in the NFC championship game, and 49ers vs Rams predictions appear to be fairly even on both sides as the line hasn’t moved early in the week. The total in this matchup between NFC West rivals has also remained steady at 46.5 points. The UNDER is 4-2 in the last six games between the 49ers and Rams.

Get the best 49ers vs Rams odds and lines available from our recommended sportsbooks for your favorite picks of the night.

  • Best Spread
    -105
    -104
    SF+3.5
    -3.5LAR
  • Best Moneyline
    +165
    -175
    SF
    LAR
  • Best Total
    -109
    -107
    Over45.5
    46Under

San Francisco Has Pulled Off Three Straight Upset Wins

The 49ers defense was able to hold Aaron Rodgers in check last Saturday, limiting the likely back-to-back MVP winner to 225 passing yards and no touchdown passes in a 13-10 upset win as 6-point road underdogs.

San Francisco tied the game 10-10 with a blocked punt returned for a touchdown in the fourth quarter and then won the game on a field goal as time expired. Jimmy Garoppolo went just 11-for-19 with 131 passing yards, no touchdown passes and an interception in the victory.

San Francisco is now 4-0 SU and ATS over its last four games, including a 3-0 SU and ATS record in its last three games as an underdog. The 49ers have won each of their last four games as an underdog outright, including two wins as 3.5-point underdogs against the Rams.

Trent Williams and Deebo Samuel were both banged up against the Packers, but neither was seriously hurt and both are currently expected to play on Sunday.

Los Angeles Must Solve The 49ers To Advance

The Rams appeared to have their divisional-round game against the Tampa Bay Buccaneers well in hand with a 27-3 lead in the second half, but a series of errors and mistakes gave Tom Brady and the Buccaneers new life and allowed them to tie the game at 27-27 with 42 seconds left. Matthew Stafford and Cooper Kupp connected for two deep passes in those 42 seconds to get Los Angeles into field-goal range, and the Rams escaped with a 30-27 road win.

Stafford is now 41-for-55 with 568 passing yards, four touchdowns and no interceptions this postseason. Kupp hauled in nine catches for 183 yards and a touchdown against the Buccaneers.

Los Angeles should be a popular 49ers vs Rams prediction given the team’s strong play on both sides of the ball and their 7-1 SU and 6-2 ATS record over their last eight games, but it’s hard to ignore San Francisco’s dominance in this head-to-head series.

49ers vs Rams Pick & Insights

49ers: Keys To Cover

Jimmy Garoppolo isn’t going to outduel Matthew Stafford if this game breaks down into a shootout. Another strong defensive effort from San Francisco will be the key to cashing in as a 49ers vs Rams prediction and punching a ticket to Super Bowl 56.

Rams: Keys To Cover

The Rams had a 17-point lead at home in their last game against San Francisco and still wound up losing. Los Angeles has the better offense on paper and earned home-field advantage in this game with a stronger regular season. Overcoming the mental edge San Francisco seems to have would help Los Angeles to become a winning 49ers vs Rams pick.

Odds Shark’s Computer 49ers vs Rams Prediction: Rams -3.5

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Shark Bites
  • San Francisco is 4-1 ATS in its last 5 road games.
  • Los Angeles is 7-2 SU in its last 9 January games.
  • The UNDER is 6-1 in San Francisco’s last 7 games.

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