Cooper Kupp and the Los Angeles Rams open the 2022 season at home vs Buffalo.

NFL Week 1 Betting Odds: Rams, Bills Headline Opening Slate

The NFL machine never stops – and it just so happens that the dial has landed on Week 1. So, it’s time to look to see if we can find some value on NFL odds and props. 

Sportsbook has released lines for all the Week 1 games and there are some on the slate that are sure to get you excited for the season. 

The reigning Super Bowl champion Los Angeles Rams kick things off as 2.5-point underdogs against the visiting Buffalo Bills on Thursday, September 8, with a full Sunday of games to follow. 

Can’t wait to get in on the action? Be sure to check out our extensive list of the best NFL betting sites to get your Week 1 bets in.

NFL Week 1 Betting Lines

Be sure to check out our NFL odds page for the latest up-to-date betting odds for Week 1.

Buffalo Bills vs Los Angeles Rams Betting Odds
Buffalo Bills-2.5 (-110)O 52 (-110)
Los Angeles Rams+2.5 (-110)U 52 (-110)

Odds as of September 8 at Sportsbook

Baltimore Ravens vs New York Jets Betting Odds
Baltimore Ravens-7.0 (-115)O 44.5 (-110)
New York Jets+7.0 (-105)U 44.5 (-110)

Odds as of September 8 at Sportsbook

Cleveland Browns vs Carolina Panthers Betting Odds
Cleveland BrownsPick’em (-110)O 42.0 (-110)
Carolina PanthersPick’em (-110)U 42.0 (-110)

Odds as of September 8 at Sportsbook

Indianapolis Colts vs Houston Texans Betting Odds
Indianapolis Colts-7 (-110)O 46.0 (-110)
Houston Texans+7 (-110)U 46.0 (-110)

Odds as of September 8 at Sportsbook

Jacksonville Jaguars vs Washington Commanders Betting Odds
Jacksonville Jaguars+2.5 (-110)O 44 (-110)
Washington Commanders-2.5 (-110)U 44 (-110)

Odds as of September 8 at Sportsbook

New England Patriots vs Miami Dolphins Betting Odds
New England Patriots+3.5 (-110)O 46.5 (-110)
Miami Dolphins-3.5 (-110)U 46.5 (-110)

Odds as of September 8 at Sportsbook

New Orleans Saints vs Atlanta Falcons Betting Odds
New Orleans Saints-5.5 (-110)O 43.0 (-110)
Atlanta Falcons+5.5 (-110)U 43.0 (-110)

Odds as of September 8 at Sportsbook

Philadelphia Eagles vs Detroit Lions Betting Odds
Philadelphia Eagles-4 (-110)O 48.5 (-110)
Detroit Lions+4 (-110)U 48.5 (-110)

Odds as of September 8 at Sportsbook

Pittsburgh Steelers vs Cincinnati Bengals Betting Odds
Pittsburgh Steelers+6.5 (-110)O 44.5 (-110)
Cincinnati Bengals-6.5 (-110)U 44.5 (-110)

Odds as of September 8 at Sportsbook

San Francisco 49ers vs Chicago Bears Betting Odds
San Francisco 49ers-7.0 (-110)O 40.5 (-110)
Chicago Bears+7.0 (-110)U 40.5 (-110)

Odds as of September 8 at Sportsbook

Green Bay Packers vs Minnesota Vikings Betting Odds
Green Bay Packers-1.5 (-110)O 47 (-110)
Minnesota Vikings+1.5 (-110)U 47 (-110)

Odds as of September 8 at Sportsbook

Kansas City Chiefs vs Arizona Cardinals Betting Odds
Kansas City Chiefs-6.0 (-110)O 53.5 (-110)
Arizona Cardinals+6.0 (-110)U 53.5 (-110)

Odds as of September 8 at Sportsbook

Las Vegas Raiders vs Los Angeles Chargers Betting Odds
Las Vegas Raiders+3.5 (-115)O 52.0 (-110)
Los Angeles Chargers-3.5 (-105)U 52.0 (-110)

Odds as of September 8 at Sportsbook

New York Giants vs Tennessee Titans Betting Odds
New York Giants+5.5 (-110)O 43.5 (-110)
Tennessee Titans-5.5 (-110)U 43.5 (-110)

Odds as of September 8 at Sportsbook

Tampa Bay Buccaneers vs Dallas Cowboys Betting Odds
Tampa Bay Buccaneers-2.5 (-110)O 51.0 (-110)
Dallas Cowboys+2.5 (-110)U 51.0 (-110)

Odds as of September 8 at Sportsbook

Denver Broncos vs Seattle Seahawks Betting Odds
Denver Broncos-6.5 (-110)O 44.5 (-110)
Seattle Seahawks+6.5 (-110)U 44.5 (-110)

Odds as of September 8 at Sportsbook

Week 1 Betting Analysis

First of all, if you are new to sports betting and are unsure of how to lay a wager on the NFL, don’t worry, we have a great betting tutorial to help you feel comfortable in making your first NFL bet!

In the meantime, here are some of the best games we’re looking forward to in Week 1.

Bills vs Rams

The champs will start the defense of their title against the Buffalo Bills, one of the top teams in the league last season, who fell to the Kansas City Chiefs in the divisional round of the playoffs.

Both of these teams have Super Bowl aspirations and return with much of their respective cores intact. 

Matthew Stafford is back for his second season with the Rams and while he loses Odell Beckham Jr. and Robert Woods from his receiving corps, the Rams added veteran wideout Allen Robinson to pair with Super Bowl MVP Cooper Kupp.

Buffalo’s big addition of the offseason was former Super Bowl MVP Von Miller, who adds another pass rusher to an already formidable defense.  


Buccaneers vs Cowboys

Tom Brady and the Tampa Bay Buccaneers kick off their pursuit of another title with a trip to Jerry World to face the new-look Cowboys on Sunday Night Football.

The Bucs are running it back with a much different roster than the one that won them a Super Bowl title in 2021, but with many of the key players still intact.

Pro Bowl guard Ali Marpet is gone, as is Rob Gronkowski, Antonio Brown, Jason Pierre-Paul and Ndamukong Suh. In their place the Bucs used some high draft picks and gave contracts to former Falcons Julio Jones and Russell Gage while making a trade for former Patriots guard Shaq Mason.

On the other side, Cowboys QB Dak Prescott no longer has Amari Cooper or Cedrick Wilson at his disposal. Prescott will instead line up with CeeDee Lamb and Dalton Schultz as his top weapons with Michael Gallup injured. 

This game will be a rematch of the Sportsbook night kickoff game of last season when the Bucs squeaked out a 31-29 victory with a last-second field goal. This time around, the Bucs are -2.5 favorites.

Raiders vs Chargers 

This game features the first matchup in one of the most hyped NFL divisions in recent memory.

The Raiders finished 10-7 last season and made the playoffs. They then added maybe the best receiver in the league in Davante Adams in the offseason.

Meanwhile, the Chargers are everyone’s pick to make noise in a stacked AFC as they might have the best all-around roster in the league on paper. 

The additions of Khalil Mack and J.C. Jackson on defense were huge upgrades to an already solid unit. They also return Justin Herbert at the helm with a good group of weapons and upgraded offensive line.

This game is the marquee matchup in the late window. The Chargers are -3.5 favorites at home.