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Cooper Kupp and the Los Angeles Rams open the 2022 season at home vs Buffalo.

The NFL machine never stops – that’s why it’s never a bad time to look ahead to the beginning of the football season to see if we can find some value on NFL odds and props. 

[ol-sportsbook-bp:48:Bovada:26:Bodog] has released lines for all the Week 1 games and there are some on the slate that are sure to get you excited for the season. 

The reigning Super Bowl champion Los Angeles Rams kick things off as 1-point favorites over the visiting Buffalo Bills on Thursday, September 8, with a full Sunday of games to follow. 

Can’t wait to get in on the action? Be sure to check out our extensive list of the best NFL betting sites to get your Week 1 bet in early.

NFL Week 1 Betting Lines

Be sure to check out our NFL odds page for the latest up-to-date betting odds for Week 1.

Buffalo Bills vs Los Angeles Rams Betting Odds
Teams Spread Total
Buffalo Bills +1.0 (-115) O 52 (-110)
Los Angeles Rams -1.0 (-105) U 52 (-110)

Odds as of June 7 at [ol-sportsbook-bp:48:Bovada:26:Bodog]

Baltimore Ravens vs New York Jets Betting Odds
Teams Spread Total
Baltimore Ravens -5.5 (-110) O 45 (-110)
New York Jets +5.5 (-110) U 45 (-110)

Odds as of June 7 at [ol-sportsbook-bp:48:Bovada:26:Bodog]

Cleveland Browns vs Carolina Panthers Betting Odds
Teams Spread Total
Cleveland Browns -3.5 (-105) O 42.5 (-110)
Carolina Panthers +3.5 (-115) U 42.5 (-110)

Odds as of June 7 at [ol-sportsbook-bp:48:Bovada:26:Bodog]

Indianapolis Colts vs Houston Texans Betting Odds
Teams Spread Total
Indianapolis Colts -8 (-110) O 44.0 (-110)
Houston Texans +8 (-110) U 44.0 (-110)

Odds as of June 7 at [ol-sportsbook-bp:48:Bovada:26:Bodog]

Jacksonville Jaguars vs Washington Commanders Betting Odds
Teams Spread Total
Jacksonville Jaguars +4 (-110) O 44 (-110)
Washington Commanders -4 (-110) U 44 (-110)

Odds as of June 7 at [ol-sportsbook-bp:48:Bovada:26:Bodog]

New England Patriots vs Miami Dolphins Betting Odds
Teams Spread Total
New England Patriots +2.5 (-110) O 44.5 (-110)
Miami Dolphins -2.5 (-110) U 44.5 (-110)

Odds as of June 7 at [ol-sportsbook-bp:48:Bovada:26:Bodog]

New Orleans Saints vs Atlanta Falcons Betting Odds
Teams Spread Total
New Orleans Saints -5 (-110) O 41.5 (-110)
Atlanta Falcons +5 (-110) U 41.5 (-110)

Odds as of June 7 at [ol-sportsbook-bp:48:Bovada:26:Bodog]

Philadelphia Eagles vs Detroit Lions Betting Odds
Teams Spread Total
Philadelphia Eagles +4 (-110) O 46.5 (-110)
Detroit Lions +4 (-110) U 46.5 (-110)

Odds as of June 7 at [ol-sportsbook-bp:48:Bovada:26:Bodog]

Pittsburgh Steelers vs Cincinnati Bengals Betting Odds
Teams Spread Total
Pittsburgh Steelers +6.5 (-110) O 44.5 (-110)
Cincinnati Bengals -6.5 (-110) U 44.5 (-110)

Odds as of June 7 at [ol-sportsbook-bp:48:Bovada:26:Bodog]

San Francisco 49ers vs Chicago Bears Betting Odds
Teams Spread Total
San Francisco 49ers -6.5 (-110) O 42 (-110)
Chicago Bears +6.5 (-110) U 42 (-110)

Odds as of June 7 at [ol-sportsbook-bp:48:Bovada:26:Bodog]

Green Bay Packers vs Minnesota Vikings Betting Odds
Teams Spread Total
Green Bay Packers -1.5 (-110) O 49 (-110)
Minnesota Vikings +1.5 (-110) U 49 (-110)

Odds as of June 7 at [ol-sportsbook-bp:48:Bovada:26:Bodog]

Kansas City Chiefs vs Arizona Cardinals Betting Odds
Teams Spread Total
Kansas City Chiefs -3 (-110) O 53.0 (-110)
Arizona Cardinals +3 (-110) U 53.0 (-110)

Odds as of June 7 at [ol-sportsbook-bp:48:Bovada:26:Bodog]

Las Vegas Raiders vs Los Angeles Chargers Betting Odds
Teams Spread Total
Las Vegas Raiders +4 (-110) O 52.0 (-110)
Los Angeles Chargers -4 (-110) U 52.0 (-110)

Odds as of June 7 at [ol-sportsbook-bp:48:Bovada:26:Bodog]

New York Giants vs Tennessee Titans Betting Odds
Teams Spread Total
New York Giants +6.5 (-110) O 44 (-110)
Tennessee Titans -6.5 (-110) U 44 (-110)

Odds as of June 7 at [ol-sportsbook-bp:48:Bovada:26:Bodog]

Tampa Bay Buccaneers vs Dallas Cowboys Betting Odds
Teams Spread Total
Tampa Bay Buccaneers -2 (-110) O 52.0 (-110)
Dallas Cowboys +2 (-110) U 52.0 (-110)

Odds as of June 7 at [ol-sportsbook-bp:48:Bovada:26:Bodog]

Denver Broncos vs Seattle Seahawks Betting Odds
Teams Spread Total
Denver Broncos -4.5 (-110) O 41.0 (-110)
Seattle Seahawks +4.5 (-110) U 41.0 (-110)

Odds as of June 7 at [ol-sportsbook-bp:48:Bovada:26:Bodog]

Week 1 Betting Analysis

First of all, if you are new to sports betting and are unsure of how to lay a wager on the NFL, don’t worry, we have a great betting tutorial to help you feel comfortable in making your first NFL bet!

In the meantime, here are some of the best games we’re looking forward to in Week 1.

Bills vs Rams

The champs will start the defense of their title against the Buffalo Bills, one of the top teams in the league last season, who fell to the Kansas City Chiefs in the divisional round of the playoffs.

The Rams are a small 1-point favorite with the total of 52 being the second highest of the week. Both of these teams have Super Bowl aspirations and return with much of their respective cores intact. 

Matthew Stafford is back for his second season with the Rams and while he loses Odell Beckham Jr. and Robert Woods from his receiving corps, the Rams added veteran wideout Allen Robinson to pair with Super Bowl MVP Cooper Kupp.

Buffalo’s big addition of the offseason was former Super Bowl MVP Von Miller, who adds another pass rusher to an already formidable defense.  

Buccaneers vs Cowboys

Tom Brady and the Tampa Bay Buccaneers kick off their pursuit of another title with a trip to Jerry World to face the new-look Cowboys on Sunday Night Football.

The Bucs are running it back with much of the same roster that won them a Super Bowl title in 2021, with a few minor exceptions.

Pro Bowl guard Ali Marpet is gone, as is Antonio Brown, Jason Pierre-Paul and Ndamukong Suh. In their place the Bucs spent on some high draft picks and a contract for former Falcon Russell Gage.

On the other side, Cowboys QB Dak Prescott no longer has Amari Cooper or Cedrick Wilson at his disposal. Prescott will instead line up with CeeDee Lamb, Michael Gallup and Dalton Schultz as his top weapons. 

This game will be a rematch of the opening night kickoff game of last season when the Bucs squeaked out a 31-29 victory with a last-second field goal. This time around, the Bucs are -2 favorites.

Raiders vs Chargers 

This game features the first matchup in one of the most hyped NFL divisions in recent memory.

The Raiders finished 10-7 last season and made the playoffs. They then added maybe the best receiver in the league in Davante Adams in the offseason.

Meanwhile, the Chargers are everyone’s pick to make noise in a stacked AFC as they have maybe the best all-around roster in the league on paper. 

The additions of Khalil Mack and J.C. Jackson on defense were huge upgrades to an already solid unit. They also return Justin Herbert at the helm with a good group of weapons and upgraded offensive line.

This game is the marquee matchup in the late window. The Chargers are early -4 favorites on the road.