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Week 17 49ers vs. Cardinals NFL Odds

Week 17 action on Sunday will see the Cardinals looking to sneak into the playoffs at the expense of the division-rival San Francisco 49ers.

San Fran has dominated the Cards on the road, going 7-1 ATS over the past eight seasons, but the Cardinals are riding a hot streak and upset Seattle a week ago.

They also have been a moneymaker in Week 17s over the years, covering eight of 10 games in this situation. The Cardinals need this one, but have not enjoyed much success against the 49ers.

The 49ers will look to vanquish their hosts on Sunday, as they are 9-5-1 ATS versus the spread this season, while the Cardinals are 10-4-1 ATS. San Francisco is 7-8 against the total, while Arizona is 7-8 versus the number.

View San Francisco 49ers vs Arizona Cardinals Odds and Stats.

The game pits the Cardinals, currently No. 8 in our OddsShark NFL Power Rankings, against the 49ers, who rate No. 4 in the latest survey. Meanwhile, math and handicapping models run on this game predict a 28-24 victory for the 49ers.


The 49ers vs Cardinals point spread was sitting at PK at Bovada as of Thursday. The total was hovering at 42 at most shops, including 5Dimes.

In their last action, San Francisco was a 34-24 winner at home against the Falcons. They failed to cover the 14-point spread as favorites, while the combined score (58) was profitable news for OVER bettors. In their last game, the Cardinals were Week 16 winners, coming out on top of the Seahawks by a score of 17-10.

How They Match Up:
The game also pits Arizona's No. 16-ranked offense, averaging 23.93 PPG, against a 49ers defense that ranks No. 3 this week at 16.8 PPG. The Cardinals aerial game is averaging 240.2 yards per game, more than the 49ers secondary allows through the air, 209.13 YPG per game.

Defensively, the 49ers feature the league's No. 3-rated road run defense, allowing 85 yards per game. Arizona, meanwhile, ranks No. 21 in rushing offense at home.

A few 49ers at Cardinals trends to consider:
San Francisco is 8-3-1 ATS in its last 12 games
San Francisco is 5-0 SU in its last 5 games
The total has gone UNDER in 5 of San Francisco's last 7 games
San Francisco is 5-0-1 ATS in its last 6 games on the road
Arizona is 5-0-1 ATS in its last 6 games
Arizona is 7-1 SU in its last 8 games
Arizona is 5-2 ATS in its last 7 games at home
Arizona is 6-1 SU in its last 7 games at home

Next up:
San Francisco home to , Wednesday, December 31st
Arizona home to , Wednesday, December 31st