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Week 6 NFL Betting Odds Preview

Big Ben Roethlisberger makes his season debut this weekend as the Pittsburgh Steelers host the Cleveland Browns as Week 6's biggest favorite on the NFL betting lines.

With Roethlisberger returning from his four-game suspension, the Steelers' passing game should see immediate improvement and no longer be the worst-ranked attack in the NFL. In Big Ben's return, the Steelers are huge 13.5-point favorites.

Part of those big odds have to do with Roethlisberger, but most comes from facing a 1-4 Browns squad that is being forced to make their own change at QB.

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Cleveland's quarterback situation is pretty dire right now, with starter Jake Delhomme and backup Seneca Wallace both battling ankle injuries. Neither is expected to be ready to go on Sunday, which leaves the starting gig in the hands of third-stringer Colt McCoy.

The rookie QB has never taken a snap in an NFL regular season game, and he had such a tough time during the preseason that he was nearly cut. [ {URL=/Stats/Matchup/Football/NFL/9233}Steelers Browns Matchup Report{/URL} ]

This game has blowout written all over it, but don't get too cocky and dump your entire bankroll on the Steelers. Last time the Steelers and Browns met up Cleveland came away with a shocking 13-6 win as a 10-point home underdog. Before that upset the Steelers had won 12 straight against the Browns with an 8-4-1 record ATS.

The game of the day on Sunday is Dallas at Minnesota in a battle of underachievers. This is a must-win game for both sides with the loser falling to 1-4 and facing an uphill battle to make the playoffs. That's pretty low for two teams that were supposed to be Super Bowl contenders.

The Vikings are 1.5-point favorites this weekend and they've dominated this matchup for years with a 6-1 record both SU and ATS in their last seven versus Dallas. For the Vikings to maintain their winning ways Brett Favre needs to be behind center.

Elbow tendinitis has plagued Favre for weeks, and there's talk of him possibly sitting this weekend if it continues to get worse. Favre hasn't missed a game in his career, so we're expecting him to play Sunday.

As long as Favre does play the Vikings' aerial attack should revolve around Randy Moss. In his debut last week Moss was simply a deep threat, but after a week of practice he should be more involved in the overall passing game. Moss and Percy Harvin could be a lethal duo if Favre's arm is ok and he can avoid throwing game-changing interceptions.

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The Vikings and Browns aren't the only teams with injury concerns heading into Week 6. The league's injury report seems to grow longer every week, and in Week 6 there are a number of big names on it that bettors need to know about. Here's a roundup of five of the big ones:

Miami at Green Bay Odds (off board) – The Packers' injury list is a mile long and includes Ryan Grant, Jermichael Finley, Donald Lee, and Al Harris. They're all out, but the big one is Aaron Rodgers - he suffered a concussion last week, but has been cleared by doctors and should play on Sunday baring a setback.

Detroit at NY Giants Odds (-10) – The Lions will be without QB Matt Stafford for at least one more game but they're hoping WR Calvin Johnson doesn't join him on the sidelines this week. Johnson banged up his right shoulder last week and it's been slowly improving throughout the week. He could be a game-time decision on Sunday.

Seattle at Chicago Odds (-6.5) – The Bears played without Jay Cutler (concussion) last week, but  still escaped with a win. Cutler remains on the injury report, but he's only probable and is expected to start on Sunday.

New Orleans at Tampa Bay Odds (+4.5) – The Saints' running game is in shambles right now with Reggie Bush out and Pierre Thomas still hurting. Thomas hasn't played since Week 3 due to a sprained ankle and he is considered questionable to play this weekend.

NY Jets at Denver Odds (+3) – After missing the Broncos' last three game with a bad hamstring Knownshon Moreno may finally play this weekend. Moreno has come close a few times before, so monitor his status up to game time because it could change again.