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Trevoh Chalobah's Chelsea are favored in the Chelsea vs Real Madrid odds.

Chelsea FC (6-1-1) and Real Madrid (6-0-2) collide at Stamford Bridge on Wednesday in the first leg of their Champions League quarterfinal. Chelsea comes into the fixture with six straight wins in all competitions while Real Madrid is 5-0-1 in its last six games. Can the hosts knock Real Madrid out of the Champions League for the second straight year? Find out in our Chelsea FC vs Real Madrid prediction.

In addition to the Champions League Computer Pick found below, see who Gareth Wheeler is backing for his Chelsea FC vs Real Madrid best bet.

Chelsea FC vs Real Madrid Preview

Chelsea FC vs Real Madrid Odds & Analysis

Opening Odds

Chelsea FC opened as the home favorite, getting +116 on the moneyline, while Real Madrid comes in as the underdog at +262. The total was set at 2.25 goals with the OVER going 4-0 in Real Madrid’s last four games and 4-2 in Chelsea’s last six.

The two clubs have not seen each other since last year’s Champions League semifinal when the Blues took the first leg at home by a score of 2-0 – perhaps a sign of things to come for your Chelsea FC vs Real Madrid prediction.

Get the best Chelsea FC vs Real Madrid odds and lines available from our recommended sportsbooks for your favorite picks of the night.

  • Best Spread
    -123
    +110
    MAD+0.5
    -0.5CHE
  • Best Moneyline
    +290
    +110
    MAD
    CHE
  • Best Total
    -105
    -115
    Over2.25
    2.25Under

Blues Breeze Past Lille In Round Of 16

The Blues easily disposed of Lille in the Champions League Round of 16, winning the second leg 2-1 to earn a 4-1 victory on aggregate. Burak Yilmaz opened the scoring for the French side 38 minutes into the game on a penalty to bring the aggregate score to 2-1 for Chelsea, but that’s the only goal the Blues would concede. Christian Pulisic scored right before halftime to tie the match before Cesar Azpilicueta slotted home the winner in the 71st minute.

Chelsea comes into this fixture in great form, having not lost in regulation time since January 15 – a 1-0 loss to Manchester City in the English Premier League. Mason Mount has had a breakout season for the Blues, leading the club with eight goals in just 19 appearances in the Premier League while adding seven assists. Meanwhile, Timo Werner is tops for scoring in the Champions League with three goals in four matches.

Benzema’s Hat Trick Helps Real Madrid Shock PSG

Real Madrid earned a relatively surprising win over Paris Saint-Germain in the Round of 16, defeating the French giants 3-2 on aggregate. After PSG took the first leg 1-0, Real Madrid bounced back with a huge performance in the second leg, winning 3-1 at home.

Kylian Mbappe put PSG up 1-0 in the first half to give his team a commanding 2-0 lead on aggregate, but Karim Benzema came up with an incredible second-half hat trick to give Real Madrid the victory. Benzema’s third goal was his 309th with the club in all competitions, surpassing Alfredo Di Stefano for the third most in Real Madrid’s history.

Real Madrid had been in solid form with five straight victories until they suffered a 4-0 defeat to Barcelona FC on March 20. The loss marked Real Madrid’s first defeat in El Clasico since 2019, though they still remain atop the La Liga table by nine points over Sevilla.

Chelsea FC vs Real Madrid Pick & Insights

Chelsea FC: Keys To Victory

Chelsea is playing some of its best football of the season, coming into the fixture on a 14-game run without losing in regulation time. The only real question mark for the Blues is up front, with striker Romelu Lukaku in poor form and reportedly unhappy at the club. That said, Chelsea will need to find goals from somewhere, and they’ll be hoping that Mount can keep up his hot run of form to lead a club that’s currently lacking a clinical finisher up front.

Real Madrid: Keys To Victory

Benzema has been on a tear this season with 22 goals in 25 La Liga appearances, plus another eight goals in the Champions League. The Frenchman is far and away Real Madrid’s most dangerous scorer and he’ll need to play a big role again if Los Blancos are going to get past the Blues.

Odds Shark’s Computer Chelsea FC vs Real Madrid Prediction: Chelsea +100

Check out more of Odds Shark’s signature Champions League computer picks, plus our favorite sportsbooks that serve soccer customers.

Shark Bites
  • Chelsea FC is 4-0-0 in its last 4 CL home games.
  • The UNDER is 6-2 in Real Madrid’s last 8 CL games.
  • The UNDER is 2-0 in the last 2 meetings.

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