Oklahoma Sooners - NCAAF Schedule for 2021
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Sep 4, 2021 | vs Tulane | REG | W | 40-35 | L | -31 | O | 66.5 |
| Sep 11, 2021 | vs Western Carolina | REG | W | 76-0 | W | -52.5 | O | 66 |
| Sep 18, 2021 | vs Nebraska | REG | W | 23-16 | L | -22.5 | U | 62.5 |
| Sep 25, 2021 | vs West Virginia | REG | W | 16-13 | L | -17.5 | U | 56.5 |
| Oct 2, 2021 | @ Kansas State | REG | W | 37-31 | L | -12.5 | O | 53 |
| Oct 9, 2021 | @ Texas | REG | W | 55-48 | W | -4 | O | 65.5 |
| Oct 16, 2021 | vs Texas Christian | REG | W | 52-31 | W | -12.5 | O | 64.5 |
| Oct 23, 2021 | @ Kansas | REG | W | 35-23 | L | -38.5 | U | 66.5 |
| Oct 30, 2021 | vs Texas Tech | REG | W | 52-21 | W | -19 | O | 67 |
| Nov 13, 2021 | @ Baylor | REG | L | 27-14 | L | -4 | U | 63 |
| Nov 20, 2021 | vs Iowa State | REG | W | 28-21 | W | -3 | U | 59 |
| Nov 27, 2021 | @ Oklahoma State | REG | L | 37-33 | P | +4 | O | 50.5 |
| Dec 29, 2021 | vs Oregon | PST | W | 47-32 | W | -7 | O | 64 |
