WKU Hilltoppers - NCAAF Schedule for 2021
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Sep 2, 2021 | vs Tennessee-Martin | REG | W | 59-21 | W | -24 | O | 58.5 |
| Sep 11, 2021 | @ Army | REG | L | 38-35 | W | +6 | O | 52 |
| Sep 25, 2021 | vs Indiana | REG | L | 33-31 | W | +9.5 | O | 62.5 |
| Oct 2, 2021 | @ Michigan State | REG | L | 48-31 | L | +10.5 | O | 66.5 |
| Oct 9, 2021 | vs Texas-San Antonio | REG | L | 52-46 | L | -3 | O | 71 |
| Oct 16, 2021 | @ Old Dominion | REG | W | 43-20 | W | -13.5 | U | 67 |
| Oct 23, 2021 | @ Florida International | REG | W | 34-19 | L | -16.5 | U | 77.5 |
| Oct 30, 2021 | vs Charlotte | REG | W | 45-13 | W | -19.5 | U | 72 |
| Nov 6, 2021 | vs Middle Tennessee | REG | W | 48-21 | W | -17.5 | O | 66.5 |
| Nov 13, 2021 | @ Rice | REG | W | 42-21 | W | -19 | O | 61.5 |
| Nov 20, 2021 | vs Florida Atlantic | REG | W | 52-17 | W | -11.5 | O | 64 |
| Nov 27, 2021 | @ Marshall | REG | W | 53-21 | W | -1 | U | 75 |
| Dec 3, 2021 | @ Texas-San Antonio | REG | L | 49-41 | L | -3.5 | O | 74.5 |
| Dec 18, 2021 | @ Appalachian State | PST | W | 59-38 | W | -1 | O | 67.5 |
