Houston Cougars - NCAAF Schedule for 2021
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Sep 4, 2021 | vs Texas Tech | REG | L | 38-21 | L | -2.5 | U | 63 |
| Sep 11, 2021 | @ Rice | REG | W | 44-7 | W | -7.5 | O | 50.5 |
| Sep 18, 2021 | vs Grambling State | REG | W | 45-0 | W | -41 | U | 51.5 |
| Sep 25, 2021 | vs Navy | REG | W | 28-20 | L | -20 | O | 47 |
| Oct 1, 2021 | @ Tulsa | REG | W | 45-10 | W | +3.5 | O | 54 |
| Oct 7, 2021 | @ Tulane | REG | W | 40-22 | W | -6.5 | O | 60 |
| Oct 23, 2021 | vs East Carolina | REG | W | 31-24 | L | -13.5 | U | 56.5 |
| Oct 30, 2021 | vs Southern Methodist | REG | W | 44-37 | W | +1 | O | 61.5 |
| Nov 6, 2021 | @ South Florida | REG | W | 54-42 | L | -13.5 | O | 53 |
| Nov 13, 2021 | @ Temple | REG | W | 37-8 | W | -25 | U | 52.5 |
| Nov 19, 2021 | vs Memphis | REG | W | 31-13 | W | -9.5 | U | 59 |
| Nov 27, 2021 | @ Connecticut | REG | W | 45-17 | L | -32.5 | O | 54.5 |
| Dec 4, 2021 | @ Cincinnati | REG | L | 35-20 | L | +10.5 | O | 52.5 |
| Dec 28, 2021 | @ Auburn | PST | W | 17-13 | W | -1.5 | U | 49.5 |
