Penn State Nittany Lions - NCAAF Schedule for 2021
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Sep 4, 2021 | @ Wisconsin | REG | W | 16-10 | W | +5.5 | U | 48.5 |
| Sep 11, 2021 | vs Ball State | REG | W | 44-13 | W | -22.5 | U | 58.5 |
| Sep 18, 2021 | vs Auburn | REG | W | 28-20 | W | -4 | U | 53.5 |
| Sep 25, 2021 | vs Villanova | REG | W | 38-17 | L | -29.5 | O | 53 |
| Oct 2, 2021 | vs Indiana | REG | W | 24-0 | W | -12.5 | U | 54 |
| Oct 9, 2021 | @ Iowa | REG | L | 23-20 | L | +2.5 | O | 41 |
| Oct 23, 2021 | vs Illinois | REG | L | 20-18 | L | -24.5 | U | 45.5 |
| Oct 30, 2021 | @ Ohio State | REG | L | 33-24 | W | +18.5 | U | 60.5 |
| Nov 6, 2021 | @ Maryland | REG | W | 31-14 | W | -10 | U | 56.5 |
| Nov 13, 2021 | vs Michigan | REG | L | 21-17 | L | +2.5 | U | 48 |
| Nov 20, 2021 | vs Rutgers | REG | W | 28-0 | W | -14 | U | 45 |
| Nov 27, 2021 | @ Michigan State | REG | L | 30-27 | L | -3.5 | O | 51.5 |
| Jan 1, 2022 | @ Arkansas | PST | L | 24-10 | L | +3.5 | U | 51 |
