Flag Our Top Sportsbooks
50% BONUS Up To $1000
125% BONUS Up To $2500
100% BONUS Up To $750

Novak Djokovic and Serena Williams lead the way atop the tennis odds for the final Grand Slam event of the season, the U.S. Open in Flushing Meadows, New York. The tournament starts August 27.

Djokovic is the defending champion in the men's draw at the U.S. Open, as he dispatched Rafael Nadal 6-2, 6-4, 6-7, 6-1 in the final of the event last season. Djokovic, the +125 favorite at TopBet, was also runner-up to Nadal at the 2010 U.S. Open.

However, Djokovic won't have to contend with Nadal this season, as the Spaniard is nursing an injury and will skip the event. Instead, five-time U.S. Open champion Roger Federer is the second-favorite for the tournament at TopBet at +250.

Andy Murray, who is coming off an Olympic gold medal, is then at +300 odds as he tries to win the U.S. Open for the first time; he lost to Federer in the final back in 2008.

Juan Martin Del Potro rounds out the top contenders on the men's side of the U.S. Open draw at +750 to win the tournament. Del Potro won this event in 2009, upsetting Federer in a 3-6, 7-6, 4-6, 7-6, 6-2 marathon match.

Over in the women's draw it's Serena Williams listed as the heavy -110 favorite on the odds to win the U.S. Open at TopBet. Williams already won Wimbledon and the Olympics this year, and she's a three-time U.S. Open champion (1999, 2002, 2008).

Maria Sharapova is then at +450 on those tennis odds as she tries for her second career U.S. Open title - the Russian topped Justine Henin in the final of this event back in 2006.

Victoria Azarenka (+600), Petra Kvitova (+1000), and Angelique Kerber (+1800) follow those top two favorites on the odds list at TopBet, with another three-time U.S. Open champion, Kim Clijsters, back at +2000 odds to win the tournament.

Defending U.S. Open champion Samantha Stosur - who topped Serena Williams 6-2, 6-3 in last year's final - is at +2500 odds. Venus Williams, who has won this tournament twice, is listed at +5000.

Odds to Win U.S. Open (Men) at TopBet:

Novak Djokovic +125
Roger Federer +250
Andy Murray +300
Juan Martin Del Potro +750
Jo-Wilfried Tsonga +2,500
Tomas Berdych +4,000
Milos Raonic +4,000
John Isner +5,000
David Ferrer +5,000
Robin Soderling +6,000
Mardy Fish +8,000
Andy Roddick +8,000
Kei Nishikori +10,000
Richard Gasquet +10,000
Marcos Baghdatis +10,000
David Nalbandian +10,000
Sam Querry +10,000
Gael Monfils +10,000
Donald Young +10,000
Janko Tipsarevic +10,000
Feliciano Lopez +10,000
Kevin Anderson +10,000
Marin Cilic +10,000
Stanislas Wawrinka +10,000
Gilles Simon +10,000
Fernando Verdasco +10,000
Bernard Tomic +10,000
Alexandr Dolgopolov +10,000
Field (Any Other Player) +2,000

Odds to Win U.S. Open (Women) at TopBet:

Serena Williams -110
Maria Sharapova +450
Victoria Azarenka +600
Petra Kvitova +1,000
Agnieszka Radwanska +2,000
Kim Clijsters +2,000
Angelique Kerber +1,800
Samantha Stosur +2,500
Na Li +3,000
Sabine Lisicki +4,000
Caroline Wozniacki +4,000
Venus Williams +5,000
Andrea Petkovic +8,000
Kaia Kanepi +8,000
Ana Ivanovic +8,000
Marion Bartoli +8,000
Yanina Wickmayer +10,000
Svetlana Kuznetsova +10,000
Mona Barthel +10,000
Sara Errani +10,000
Tamira Paszek +10,000
Melanie Oudin +10,000
Julia Goerges +10,000
Maria Kirilenko +10,000
Anastasia Pavlyuchenkova +10,000
Francesca Schiavone +10,000
Vera Zvonareva +10,000
Shuai Peng +10,000
Jelena Jankovic +10,000
Field (Any Other Player) +1,000