Packers vs 49ers betting Odds Preview, Pick

49ers quarterback Colin Kaepernick shredded the Packers in a 45-31 playoff victory in January. Has Green Bay figured out a way to slow him down in the offseason?

The 49ers were 4 ½-point favorites with the total sitting at 41.

Green Bay lost starting offensive tackle Bryan Bulaga to an ACL injury in training camp and projected started running back Dejuan Harris to a knee injury in Week 3 of the preseason.

Pass protection is a major concern for the Packers, especially against a 49ers defense that get after the quarterback. Rookie running back Eddie Lacy must be sharp in his blitz pickups to keep Aaron Rodgers upright.

The 49ers have been fantastic at home under coach Jim Harbaugh, going 13-6-1 against the spread at Candlestick Park the past two seasons.

The Pack is 5-1 ATS past 6 season openers and has played 4 straight UNDERs when they open the season on the road.

The 49ers meanwhile are 9-3-1 ATS in their past 13 September games and 7-2-1 ATS in their past 10 season openers.

View Green Bay vs San Francisco Odds and Stats.

49ers vs Packers Betting Line:
San Francisco opened as 4.5-point favorites at shops such as Bovada, while the NFL total was set at 50.5 for over under betting at TopBet.
Power Rankings / Prediction:
The OddsShark Power Rankings have the 49ers at No. 2 and the Packers at No. 10 heading into this contest. Handicapping models project a 30-29 result in favor of the 49ers.

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Green Bay Packers Trends:
When playing in September are 7-3
When playing on grass are 9-1
After being outgained are 7-3
When playing outside the division are 6-4

San Francisco 49ers Trends:
When playing in September are 5-5
When playing on grass are 8-1-1
After outgaining opponent are 7-2-1
When playing outside the division are 8-2

A few Packers at 49ers trends to consider:
The total has gone OVER in 5 of Green Bay's last 5 games when playing San Francisco
Green Bay is 13-3 SU in its last 16 games when playing San Francisco
Green Bay is 10-3 SU in its last 13 games
Green Bay is 6-1-1 ATS in its last 8 games when playing on the road against San Francisco
The total has gone OVER in 5 of San Francisco's last 5 games
The total has gone OVER in 5 of San Francisco's last 5 games at home
The total has gone OVER in 5 of San Francisco's last 5 games when playing Green Bay
San Francisco is 4-1 SU in its last 5 games at home

Next up:
Green Bay home to Washington, Sunday, September 15
San Francisco at Seattle, Sunday, September 15

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