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MNF: Chargers vs. Cards on Monday night

The Arizona Cardinals have paid off just once in their last eight games on Monday Night Football dating back to 1995 as they close out the Week 1 NFL betting slate on Monday at home against the San Diego Chargers.

Arizona is 1-6-1 ATS in their last eight MNF outings, while San Diego has posted a 4-1 ATS mark in their last five games on Monday night. The Chargers are also a lucrative 8-1-1 ATS in their last 10 games as underdogs on the road for bettors on the NFL odds.

The Cardinals are 5-1 ATS past six openers but just 2-7 SU vs the Chargers since 1987. San Diego meanwhile is 8-1-1 ATS past 10 games as road underdogs. The Cards have struggled to a 2-10 SU mark vs AFC West teams since 2002.

San Diego Chargers vs Arizona Cardinals Opening Odds and Betting Line

The San Diego Chargers were listed as 3-point Monday Night Football underdogs at sportsbooks such as Bovada, with the total listed at 44.5 over at BetDSI.

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Computer Prediction: San Diego Chargers vs Arizona Cardinals Pick

Handicapping models based on recent betting stats and prediction formulas pick a 26-24 win for the Cardinals. View the computer score prediction and who will win the pick on the moneyline for all upcoming NFL matchups here.

San Diego Chargers vs Arizona Cardinals Odds and Stats.

Team Betting Records & Power Rankings

Supporters of the San Diego Chargers have seen them go 10-8 and 11-6-1 ATS so far this season, while the Arizona Cardinals are at 10-6 and 10-5-1 ATS. In totals betting, the Cardinals are 8-8, while the Chargers are 7-11. Stay Informed: follow us on Twitter for odds specials, betting line moves and Arizona vs San Diego injuries news.

The game pits the Arizona Cardinals, currently No. 7 in our Odds Shark NFL Power Rankings, against the San Diego Chargers, who rate No. 10 in the latest survey.

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How San Diego Chargers vs Arizona Cardinals Stats Matchup

Offensively, the game matches up the Arizona Cardinals No. 16-ranked offense (23.69 PPG) against a San Diego Chargers defense that ranks No. 9 at 21.22 PPG. The Cardinals passing attack has averaged 250.12 yards per game, less than the Chargers give up through the air (260.83 YPG on average).

In comparing defenses, the San Diego Chargers own the league's No. 14-rated front 7 in terms of stopping the run, allowing 114.3 yards per game when on the road. Arizona, on the other hand, rates No. 24 this week in generating rushing yards at home.

Recent Outings Betting Recap

The Chargers were a 24-17 loser in their most recent outing on the road against the Broncos. They covered the 7.5-point spread as underdogs, while the total score (41) made winners of UNDER bettors. In their last gridiron battle, Keenan Allen did much of the damage, producing 142 receiving yards but San Diego managed to defeat the Chargers 24-17 at Sports Authority Field at Mile High.

Arizona lost its last outing, a 23-20 result against the 49ers on December 29. The Cardinals failed to cover in that game as a 3-point favorite, while the 43 combined points took the game OVER the total. In their last game, Arizona's aerial attack generated 407 yards but it was the 49ers coming away with a 23-20 victory over Arizona at University of Phoenix Stadium.

San Diego Chargers vs Arizona Cardinals Betting Odds Trends

San Diego is 5-1 ATS in its last 6 games
San Diego is 5-1 SU in its last 6 games
The total has gone UNDER in 4 of San Diego's last 5 games
San Diego is 4-1 ATS in its last 5 games on the road
Arizona is 5-1-1 ATS in its last 7 games
Arizona is 7-2 SU in its last 9 games
Arizona is 4-1 SU in its last 5 games at home
The total has gone OVER in 4 of Arizona's last 6 games at home

Next Betting Matchups

San Diego home to Seattle, Sunday, September 14th
Arizona at New York, Sunday, September 14th