Chicago White Sox vs Chicago Cubs in MLB Betting Odds

The Chicago White Sox will look to pick up a road win when they take on the Cubs in Chicago at Wrigley Field on Sunday in MLB baseball betting odds action.

Jake Arrieta gets the call for the Chicago Cubs and he will try to build on a 9-5 mark. In the other dugout, Jose Quintana brings a 4-8 ledger to the game for the Chicago White Sox as he tries to quiet the Cubs bats.

Odds Shark computer prediction handicapping models run on this game pick a 4-2.8 victory for the Cubs. View the computer score prediction and who will win the pick on the moneyline for all upcoming MLB matchups here.

Chicago White Sox vs Chicago Cubs Matchup

Team Betting Records & Power Rankings

46-40 Chicago battles the White Sox, currently with a 41-44 mark. Stay Informed: follow us on Twitter for odds specials, betting line moves and Chicago vs Chicago injuries news.

The Odds Shark MLB Power Rankings have the Chicago Cubs at No. 10 and the Chicago White Sox at No. 20 heading into this contest.

Statistical Matchup

Offensively, the game matches up Chicago Cubs No. 24 ranked offense (3.86 runs per game) against a Chicago White Sox defense and pitching staff that sits at No. 19 at 4.26 runs allowed per game. The Chicago Cubs have been averaging 8.09 hits per game, less than the Chicago White Sox have managed so far this season (8.21 hits on average).

Chicago brings the No. 19-rated defense to this matchup, facing the Cubs's No. 6-ranked defense.