Chicago White Sox take on the Cleveland Indians with Odds and Betting Pick

The Cleveland Indians will look to bolster their win total and reward those moneyline betting when the Chicago White Sox invade Progressive Field on Wednesday.

Cleveland sends Danny Salazar out against Derek Holland for the Chicago White Sox in this game. Salazar is 0-0 with a 6.35 ERA on the season, while Holland is 0-1 on the year and has a 3.00 ERA.

Sportsbook Odds & Computer Pick

The visiting Chicago White Sox were 203 moneyline underdogs in this one earlier in the day at most online sportsbooks including Sportsbook. The total was 8.5 at Sportsbook for those preferring over under betting.

Prediction-scoring formulas run on this game pick a potential 4.0-3.0 result in favor of the White Sox. View the computer score prediction and who will win the pick on the moneyline for all upcoming MLB matchups here.

Chicago White Sox vs Cleveland Indians Matchup

Team Betting Records & Power Rankings

The Cleveland Indians bring a 4-3 record to the battle against the 2-4 White Sox. Stay Informed: follow us on Twitter for odds specials, betting line moves and Cleveland vs Chicago injuries news.

This game matches up the No. 17 (Cleveland Indians) and the No. 16 (Chicago White Sox) teams, according to our current MLB Power Rankings.

Statistical Matchup

On offense, it's a battle between the Cleveland Indians and its No. 14-rated batting order, averaging 4.29 runs per nine innings, against the No. 19 line up of the Chicago White Sox at 3.83 runs per outing.

Defensively, Chicago features the No. 1-rated defense on the road, allowing 2 runs per game. Cleveland, meanwhile, comes in at No. 28 at home, scoring 2 runs per game.